Table 1: S100A8/S100A9 functions and association with inflammatory conditions.
Function | Ref |
Murine: - Neutrophil and monocyte chemotaxis (S100A8) | [43-56] |
- Activate TLR4 and amplify inflammatory responses (S100A8) | [9] |
- Inhibit macrophage spreading and phagocytosis of adherent | |
peritoneal cells (S100A9) | [57] |
- Oxidant scavenger (S100A8) | [56] |
- Reduce H2O2 release from activated macrophage (S100A9) | [58] |
Human: - Neutrophil chemotaxis (S100A8/S100A9) | [43,44] |
- Upregulate Mac-1 expression (S100A8 / S100A9) | [43,44] |
- Promote intercellular arachidonic acid transport (S100A8/S100A9) | [18] |
- Antimicrobial defense (S100A8/S100A9) | [59] |
- Inhibit fibrin formation (S100A9) | [60] |
- Sequester intracellular Zn2+ (S100A8/S100A9) | [61] |
- Oxidant scavenger and NO shuttle (S100A8) | [22,62] |
- Reduce H2O2 release from activated macrophage (S100A9) | [58] |
- Proinflammatory; enhance expression of proinflammatory cytokines | |
and adhesion molecules (S100A8/S100A9) | [63,64] |
- Anti-inflammatory; recombinant proteins reduced LPS-induced systemic | |
release of IL-6 and NO in rats (S100A8/S100A9) | [65] |
Association with inflammatory disease/disorder | |
Murine: - Arthritis (S100A8/S100A9) | [66] |
- Abdominal sepsis | [55,67] |
- Pneumonia-derived sepsis | [68] |
- LPS-induced endotoxemia | [65,69] |
- Autoimmune myocarditis | [70] |
Human: - Arthritis (S100A8/S100A9) | [71-73] |
- Inflammatory bowel disease (S100A8/S100A9) | [74] |
- Systemic inflammation (S100A8/S100A9) | [75,76] |
- Pancreatitis (S100A8/S100A9) | [77] |
- Sepsis (S100A8/S100A9) | [67-79] |
- Lupus erythematosus | [80] |