Table 2: FISH findings for the 20 metastatic melanomas. Specimens were designated FISH positive if at least one of four criteria listed in table 4 were met. Values rendering a FISH positive result are highlighted in bold.

 

Subject

Mean RREB1

RREB1 % abnormal (n/60)

Mean MYB

MYB % loss (n/60)

Mean CCND1

Mean CEP6

FISH Result

M1

2.90

80.0% (48/60)

1.50

13.5% (8/60)

2.45

1.18

+

M2

2.75

50.0% (30/60)

2.23

42% (25/60)

2.47

2.38

+

M3

2.22

33.0% (20/60)

1.20

58% (35/60)

2.08

1.92

+

M4

2.43

53.0% (32/60)

1.67

10.5% (6/60)

1.72

1.54

-

M5

4.30

93.5% (56/60)

2.23

36.5% (22/60)

2.20

2.55

+

M6

3.67

88.5% (53/60)

3.08

20% (12/60)

2.94

2.94

+

M7

3.83

93.5% (56/60)

1.42

70% (42/60)

1.97

2.62

+

M8

4.03

90.0% (54/60)

2.38

76.5% (46/60)

3.23

3.52

+

M9

2.84

71.5% (43/60)

1.47

65% (39/60)

2.18

2.70

+

M10

2.62

58.3% (35/60)

2.30

13.5% (8/60)

3.28

2.10

+

M11

3.45

81.7% (49/60)

2.39

8.64% (5/60)

2.42

2.35

+

M12

2.75

72.0% (43/60)

1.55

25.3% (15/60)

2.92

2.12

+

M13

3.59

83.5% (50/60)

1.75

35.17% (21/60)

2.37

2.38

+

M14

2.60

70.0% (42/60)

0.98

6.82% (4/60)

2.37

1.99

+

M15

2.87

78.5% (47/60)

1.64

21.72% (13/60)

1.78

1.97

+

M16

3.77

52.4% (31/60)

2.18

13.77% (8/60)

3.17

3.35

+

M17

3.60

79.8% (48/60)

1.68

31.72% (19/60)

1.87

2.77

+

M18

4.05

95.0% (57/60)

1.68

45.25% (27/60)

2.17

2.82

+

M19

2.60

49.1% (29/60)

1.89

14.04% (8/60)

2.02

2.19

-

M20

3.17

83.33% (50/60)

2.70

30.00% (18/60)

2.33

2.73

+