Effect of IRC on Fasting Blood Glucose Level in Diabetic Rats After Repeated (Multiple) Dose Administration.

Table 3: Effect of IRC on Fasting Blood Glucose Level in Diabetic Rats After Repeated (Multiple) Dose Administration.

Group	Dose Mg/kg	Before alloxan	2 days after Alloxan (o hr)	Blood glucose Level(mg/dl) at different time intervals (days)
Group	Dose Mg/kg	Before alloxan	2 days after Alloxan (o hr)	Day 1	Day 3	Day 5	Day 7	Day 14	Day 21	ANOVA
I-Diabetic Control	-	92.69 ± 3.02	373.80 ± 11.98	335.80 ± 15.44	378.50 ± 4.75	379.00 ± 24.81	355.80 ± 10.46	275.50 ± 8.83	277.50 ± 9.61	< 0.0001
II-Diabetic + IRC	5	88.00 ± 4.55	348.30 ± 11.84	322.20 ± 20.52	368.00 ± 13.94	362.20 ± 19.73	343.80 ± 18.81	270.00 ± 4.09	271.50 ± 4.09	0.0531
III-Diabetic + IRC	50	97.19 ± 2.04	324.50 ± 19.08	289.00 ± 15.84	242.00 ± 15.99	261.20 ± 8.37	237.80 ± 17.70	218.00 ± 9.16	216.50 ± 6.05	< 0.0001
IV-Diabetic + IRC	250	84.50 ± 1.89	328.50 ± 15.83	269.70 ± 16.86	233.30 ± 12.98	243.50 ± 26.48	181.50 ± 9.02	205.50 ± 7.19	208.00 ± 4.75	< 0.0001
V-Diabetic + IRC	500	99.83 ± 3.34	338.00 ± 13.60	262.00 ± 17.90	225.50 ± 13.09	222.70 ± 17.39	159.70 ± 8.00	188.20 ± 7.09	196.30 ± 3.44	< 0.0001
Dose depend effect				0.0184	0.0006	< 0.0001	< 0.0001	< 0.0001	< 0.0001
VI-Diab + Gliben	5	96.33 ± 4.46	320.30 ± 9.88	236.00 ± 17.9	194.30 ± 15.16	179.00 ± 10.90	148.70 ± 10.16	169.80 ± 7.56	186.33 ± 4.46	< 0.0001

Each value represent mean ± SEM (n = 6 rats per group).