Comparing premix human insulin vs. premix insulin analogues.

Table 8: Comparing premix human insulin vs. premix insulin analogues.

Glycaemic control
Name of study	Study population size (n)	Patients included	Drugs compared	Inference	p Value
Matto, et al. [38]	n = 151	Type 2 diabetes	Insulin lispro 75/25 vs. Human insulin 70/30	Reduction in mean 4 point blood glucose profile: Insulin lispro > Human insulin	p = 0.004
Malone, et al. [39]	n = 84	Type 2 diabetes	Insulin lispro 75/25 vs. Human insulin 70/30	PP blood glucose excursion: Lower with insulin lispro than human insulin	p < 0.001
				AUC in glucose concentration - time curve: Less in insulin lispro than human insulin	----
Christiansen, et al. [40]	n = 403	Type 2 diabetes	BI Asp 30 vs. NPH (BD)	Comparable reduction in HbA1c with both (0.67% with BI Asp 30 0.61% with NPH)	----
				PP increment over 3 meals: Lower with BI Asp 30 than NPH	p < 0.0001
Boehm, et al. [41]	n = 294	Type 1 diabetes and Type 2 diabetes	BI Asp 70/30 vs. Human insulin 70/30	Reduction in HbA1c: Similar with both	----
				PP blood glucose control: BI Asp > Human Insulin	----
PP: Post Prandial; AUC: Area Under Curve; BI Asp: Biphasic Insulin Aspart.