The causes of secondary drug failure to Oral hypoglycemic agents [31].

Table 2: The causes of secondary drug failure to Oral hypoglycemic agents [31].

The patient factors

Disease related factors

• An improper diet

• Obesity

• Lack of exercise

• Lack of knowledge of diabetes and stress

• An impaired C-peptide response to a meal

• An enhanced basal rate of hepatic glucose production which is insufficiently suppressed by insulin

• Impaired storage of glucose as glycogen