Major islet ECM components and their corresponding receptors.

Table 1: Major islet ECM components and their corresponding receptors.

ECM protein	Location and Function	Receptors on islet cells
Type I collagen	Peri- and intra-islet ECM, provides tensile strength, structural integrity, and survival signalling.	α_vβ₃, α₂β₁, DDR2
Type IV collagen	Basement membrane, provides microstructural integrity and cell stimulation, attaches to other basement membrane components.	α₁β₁, DDR1
Fibronectin	Basement membrane, arranged in a 3D fibrillar mesh similar to collagen, plays import roles in cell adhesion and development.	α_vβ₁, α_vβ₃, α₅β₁
Laminin	Basement membrane, glycoprotein with trimeric structure, important for cell binding, migration, and differentiation.	α₁β₁, α₃β₁, α₅β₁, α₆β₁