Table 4.
Qualitative summary of effect of pharmacologic agents studied for
diabetes prevention [22]
|
Pharmacologic
agent |
Diabetes incidence |
Cardiovascular disease |
Cancer |
Fracture |
Other |
|
Metformin |
↓ |
↓ |
↓ |
- |
GI
Events |
|
Acarbose
|
↓ |
↓ |
- |
- |
GI
Events |
|
Rosiglitazone |
↓ |
↑ |
- |
↑ |
↑Non-fatal
congestive heart failure, weight gain and edema |
|
Nateglinide |
No
effect |
No
effect |
- |
- |
|
|
Ramipril
|
No
effect |
↓ |
No
effect |
- |
|
|
Valsartan |
↓ |
↓ |
No
effect |
- |
|
|
Insulin |
↓ |
No
effect |
No
effect |
No
effect |
↑Hypoglycaemia
↑ Body weight |