Table 9: GRADE table of evidence (created using https://www.GradePro.com).

Certainty assessment

№ of patients

Effect

Certainty

Importance

№ of studies

Study design

Risk of bias

Inconsistency

Indirectness

Imprecision

Other consideration

metronomic chemotherapy

without metronomic chemotherapy

Relative
(95% CI)

Absolute
(95% CI)

Overall response rate (assessed with RECIST guidelines version 1.1)

2

randomised trials

serious

not serious

not serious

not serious

None

44/71 (62.0%)

32/67 (47.8%)

RR 1.29
(0.95 to 1.75)

139 more per 1,000
(from 24 fewer to 358 more)

⨁⨁⨁◯
Moderate

IMPORTANT

CI: Confidence Interval; RR: Risk Ratio