Table 4: Details of Premature Menopausal Patients (N = 7).

SN

Year

Age

Stage

Histology

Chemotherapy

Cycle

site

Primary surgery

Note

25

2017

29

IIA

Yolk sac tumor

BEP

6

right

Right SO and omentectomy 6/1/2017

16/1/18 abdominal pain& pelvic mass size 10x15 cm, solid and cystic, movable AFP 2.2 à TAHand left SO 19/1/18 à endometrioid CA IA à carboplatin x 6 à complete response à DFS 61 mo, HRT

43

2014

16

III

Dysgerminoma

BEP

4

bilateral

Left SO &omentectomy

Partial response during BEP, overall survival 3 months, death from sepsis (neutropenia)

52

2013

15

IV

Yolk sac tumor

BEP

8

right

Right salpigo-oophorectomy with left ovarian cystectomy

PFS 15 mo.àTIP x 2 cycles à PT x 1 àifosfamide x 1 cycle à death os 16 mo,

87

2008

28

I

Dysgerminoma

BEP

3

left

Left SO

HRT cycloprogynova, lost to follow up since 2009, unknown status

108

2005

15

III

Yolk sac tumor

BEP

6

right

Right SO

Febrile neutropenia à sepsis à death 2005 os 9 mos

110

2005

16

IV

Yolk sac tumor

BEP x 2 à EP x 11

12

right

 

Progression after EP x 11 àifosfamide x 1 à EMA x 1 à single paclitaxel x 1 à palliative RT 25/1/2006 à VAC x 1 àDeath 4/7/2007,OS 30 mo.

(lung fibrosis after BEP x 2)

114

2005

23

II

dysgerminoma

BEP

6

right

Right SO

Alive, loss after 12 mo. since start treatment, no HRT

 

BEP: Bleomycin+Etoposide+Cisplatin; SO: Salpingo-Oophorectomy; TAH: Total Abdominal Hysterectomy; AFP: Alpha-Fetoprotein; DFS: Disease Free Survival; HRT: Hormonal Replacement Therapy; PFS: Progression Free Survival, TIP: paclitaxel + ifosfamide + cisplatin; PT: paclitaxel+carboplatin, OS: Overall Survival; EP: Etoposide+Cisplatin, EMA: Etoposide+ Methotrexate+ Actinomycin D; palliative RT: radiotherapy