Table 4: Details of Premature Menopausal Patients (N = 7).
SN |
Year |
Age |
Stage |
Histology |
Chemotherapy |
Cycle |
site |
Primary surgery |
Note |
25 |
2017 |
29 |
IIA |
Yolk sac tumor |
BEP |
6 |
right |
Right SO and omentectomy 6/1/2017 |
16/1/18 abdominal pain& pelvic mass size 10x15 cm, solid and cystic, movable AFP 2.2 à TAHand left SO 19/1/18 à endometrioid CA IA à carboplatin x 6 à complete response à DFS 61 mo, HRT |
43 |
2014 |
16 |
III |
Dysgerminoma |
BEP |
4 |
bilateral |
Left SO &omentectomy |
Partial response during BEP, overall survival 3 months, death from sepsis (neutropenia) |
52 |
2013 |
15 |
IV |
Yolk sac tumor |
BEP |
8 |
right |
Right salpigo-oophorectomy with left ovarian cystectomy |
PFS 15 mo.àTIP x 2 cycles à PT x 1 àifosfamide x 1 cycle à death os 16 mo, |
87 |
2008 |
28 |
I |
Dysgerminoma |
BEP |
3 |
left |
Left SO |
HRT cycloprogynova, lost to follow up since 2009, unknown status |
108 |
2005 |
15 |
III |
Yolk sac tumor |
BEP |
6 |
right |
Right SO |
Febrile neutropenia à sepsis à death 2005 os 9 mos |
110 |
2005 |
16 |
IV |
Yolk sac tumor |
BEP x 2 à EP x 11 |
12 |
right |
|
Progression after EP x 11 àifosfamide x 1 à EMA x 1 à single paclitaxel x 1 à palliative RT 25/1/2006 à VAC x 1 àDeath 4/7/2007,OS 30 mo. (lung fibrosis after BEP x 2) |
114 |
2005 |
23 |
II |
dysgerminoma |
BEP |
6 |
right |
Right SO |
Alive, loss after 12 mo. since start treatment, no HRT |
BEP: Bleomycin+Etoposide+Cisplatin; SO: Salpingo-Oophorectomy; TAH: Total Abdominal Hysterectomy; AFP: Alpha-Fetoprotein; DFS: Disease Free Survival; HRT: Hormonal Replacement Therapy; PFS: Progression Free Survival, TIP: paclitaxel + ifosfamide + cisplatin; PT: paclitaxel+carboplatin, OS: Overall Survival; EP: Etoposide+Cisplatin, EMA: Etoposide+ Methotrexate+ Actinomycin D; palliative RT: radiotherapy