Table 3: Association of PhIP with Esophageal squamous cell carcinoma, PADRE study 2020.
Characteristic |
Model 1 Adjusted Odds Ratio (95%CI) |
Model 2 Adjusted Odds Ratio (95%CI) |
Model 3 Adjusted Odds Ratio (95%CI) |
Akaike's information criterion |
123 |
121 |
86 |
Age (each decade in years) |
0.79 (0.47, 1.31) |
0.79 (0.45, 1.41) |
0.82 (0.45, 1.50) |
Gender |
|
|
|
Women, n (%) |
Ref |
Ref |
Ref |
Men, n (%) |
0.33 (0.05, 2.09) |
0.29 (0.04, 1.91) |
0.46 (0.06, 3.47) |
Asset index |
|
|
|
Low |
0.64 (0.19, 2.14) |
0.51 (0.14, 1.89) |
0.43 (0.10, 1.74) |
Fair |
Ref |
Ref |
Ref |
High |
0.73 (0.21, 2.55) |
0.57 (0.15, 2.15) |
0.68 (0.16, 2.88) |
Cigarette smoking (pack years) |
|
|
|
1 |
Ref |
Ref |
Ref |
2 to 3 |
4.93 (1.48, 16.42) |
6.97 (1.87, 26.01) |
7.75 (1.90, 31.50) |
3 or more |
5.42 (1.41, 20.89) |
5.55 (1.30, 23.72) |
5.82 (1.25, 27.11) |
Alcohol use (number of drinks per day) |
|
|
|
1 to 2 per day |
Ref |
Ref |
Ref |
3 to 4 per day |
5.92 (2.02, 17.39) |
6.55 (2.06, 20.85) |
8.00 (2.31, 27.74) |
5 or more per day |
5.35 (1.03, 27.75) |
6.55 (1.07, 39.93) |
5.71 (0.89, 36.49) |
Primary cooking fuel |
|
|
|
Charcoal |
|
Ref |
Ref |
Firewood |
|
1.87 (0.03, 25.04) |
0.63 (0.01, 20.99) |
Cooking place |
|
|
|
Outside in compound |
|
Ref |
Ref |
Inhouse (separate room) |
|
2.13 (0.13, 35.51) |
0.33 (0.01, 11.37) |
Inhouse (bedroom) |
|
0.28 (0.01, 9.34) |
2.78 (0.15, 49.09) |
Meat consumption weekly |
|
|
|
Lower |
|
|
1.70 (0.43, 6.62) |
Middle |
|
|
Ref |
Higher |
|
|
1.36 (0.31, 5.96) |
PhIP normalized (ng/g melanin) |
|
|
|
< 8.65 (75% percentile) |
|
|
Ref |
≥ 8.65 (75% percentile) |
|
|
4.27 (1.12, 16.24) |
CI: Confidence Interval