Related fucntions with liver diseases Ref. Association with liver cancer Ref.
Ligands Jagged1 mutation: Alagille syndrome [31] upregulation: cancer, poor prognosis [65]
copy number gain: cancer, poor prognosis [57]
Jagged2 NR NR
DLL1 NR NR
DLL3 NR NR
DLL4 fibrosis and NASH pathogenesis [52] HBV-x relation [90]
Receptors Notch1 biliary differentiation from HPCs by autophagy [77] upregulation: cancer, poor prognosis [78]
HBV-x relation [90]
Notch2 bile duct development [80] aggressiveness of liver cancer [79]
relation with hepatoblastoma [82] HPCs: dedifferentiated liver cancer [81]
genomic abnormality: Alagille syndrome [34]
Notch3 diffentiation and progression of cholangiocarcinoma [83] HBV-x relation [90]
modulating the stemness of tumor cells [84]
Notch4 hepatocytic-liniage commitment of HPCs [87] upregulation: cancer, poor prognosis [88]
HBV-x relation [90]

NR: not definitely reported; HPCs: hepatocyte progenitor cells; NASH: nonalcoholic steatohepatitis.