Table 5: Details in patients with brain metastases.

Number of patients (%)
Total 14
Number of previous regimens for metastatic breast cancer
0 0
1 4 (29%)
2 2 (14%)
3 4 (29%)
≥ 4 4 (29%)
Loco-regional treatment for brain metastases
None 1 (7%)
Surgery 0
Radiation therapy 12 (86%)
Surgery + radiation therapy 1 (7%)
Response to T-DM1 for brain metastases
Complete response 0
Partial response 0
Stable disease 5 (36%)
Progressive disease 5 (36%)
Not evaluable 4 (29%)
Median time to treatment failure, months (range) 6.0 (0.8-21.0)
Adverse events (Grade 3/4)
Thrombocytopenia 3 (21%)
Increased ALT and/or AST 0
Rash 0
Neutropenia 0