Table 1: Relapse crude cumulative incidence regression model based on pseudo-values. For each covariate the exponent of regression coefficient is estimate of the ratio between crude cumulative incidences. N0 and N1 indicates absence or presence of axillary lymph node metastases respectively. T is pathological tumour size (in cm). PgR +,- indicates > 25 or <= 25 femtomoles progesterone receptors per milligram of cytosolic protein respectively, ER +,- indicates > 10 fmoli or <= 10 of estrogen receptors femtomoles per milligram of cytosolic protein respectively and Time, time’ and time’’ represents spline basis for time.

 

Estimate

Standard Error

Wald statistic

p-value

(Intercept)

-5.074

0.387

172.11

< 0.001

time

0.07

0.008

81.643

< 0.001

time'

-0.284

0.041

47.427

< 0.001

time''

0.48

0.074

42.294

< 0.001

PGR (+ vs. -)

0.083

0.142

0.339

0.561

ER (+ vs. -)

0.313

0.172

3.317

0.069

T (1-2 vs ≤ 1)

0.628

0.187

11.323

0.001

T (> 2 vs. ≤ 1)

0.888

0.203

19.207

< 0.001

N (1 vs. 0)

0.163

0.112

2.117

0.146

age (41-50 vs. ≤ 40)

-0.245

0.162

2.272

0.132

age (51-60 vs. ≤ 40)

-0.229

0.168

1.861

0.172

age (> 60 vs. ≤ 40)

-0.63

0.21

9.044

0.003