Table
3: Univariate
and Multivariable Cox regression analyses of PPS.
|
|
PPS |
|||
Variable |
Reference |
Univariate |
Multivariate |
||
Hazard
Ratio (95% CI) |
p
Value |
Hazard
Ratio (95% CI) |
p
Value |
||
Age ≥`65 |
< 65 |
1.09 (0.58-2.03) |
0.80 |
1.05 (0.53-2.09) |
0.89 |
ER positive |
ER negative |
1.24 (0.64-2.38) |
0.56 |
0.57 (0.26-1.24) |
0.16 |
Prior lines of chemotherapy ≥ 2 |
< 2 |
1.05 (0.44-2.53) |
0.91 |
0.46 (0.17-1.22) |
0.12 |
Total dose of Eribulin
≥ 10 mg/m2 |
< 10 mg/m2 |
0.59 (0.30-1.17) |
0.132 |
0.26 (0.12-0.57) |
0.001 |
Visceral disease |
Non-visceral |
3.17 (1.29-7.76) |
0.012 |
7.33 (2.49-21.6) |
< 0.001 |
A new lesion or metastasis |
IPEL |
2.07 (1.08-3.96) |
0.029 |
2.84 (1.34-6.02) |
0.006 |
IPEL: in size
of pre-existing lesion