Table 1: List of cancer
hallmark pathways with supporting literature. PMID – Pubmed
ID of the article used for pathway reconstruction. Cancer hallmark processes
are borrowed from [13].
Cancer Hallmark |
Pathway Name |
Number of entities |
Number of relations |
Publication PMIDs |
Sustaining proliferation |
EGFR activation by apoptotic clearance |
69 |
91 |
16000554,
12069816, 15273989 |
Sustaining proliferation |
Cell
cycle |
144 |
225 |
Available
in Pathway Studio |
Sustaining proliferation |
Bombesin trans-activation of EGFR |
51 |
75 |
12069816,
16377102 |
Sustaining proliferation |
F2
-> AP-1/CREB/ELK-SRF/SP1 Expression Targets |
128 |
200 |
Available
in Pathway Studio |
Sustaining proliferation |
DREAM
complex->quiescence |
27 |
36 |
23842645 |
Resisting cell death |
Extrinsic
and Intrinsic Apoptosis pathways |
100 |
166 |
Available
in Pathway Studio |
Resisting cell death |
Hypoxia->ROS->Apoptosis |
45 |
62 |
11266442,
|
Resisting cell death |
oxLDL->apoptosis |
20 |
18 |
|
Resisting cell death |
F2
-> STAT1/NF-kB Expression Targets |
94 |
102 |
Available
in Pathway Studio |
Angiogenesis |
Hypoxia->ROS->HIF->Angiogenesis |
49 |
88 |
|
Angiogenesis |
Blood
vessel maturation and stability |
54 |
90 |
|
Angiogenesis |
VEGFR->endothelial
proliferation |
74 |
151 |
|
Angiogenesis |
oxLDL->angiogenesis |
57 |
66 |
|
Angiogenesis |
TNC->angiogenesis |
47 |
81 |
|
Angiogenesis |
F2->Angiogenesis |
35 |
51 |
15598469 |
Invasion & Metastasis |
ICAM1
-> AP-1/CREB/ELK-SRF signaling |
29 |
51 |
Available
in Pathway Studio |
Invasion & Metastasis |
Wnt ->EMT |
52 |
72 |
|
Invasion & Metastasis |
Hypoxia->EMT |
43 |
76 |
|
Invasion & Metastasis |
FGFs
stabilize RUNX2 |
47 |
67 |
12110689,
12403780 |
Invasion & Metastasis |
TGFB
loop |
116 |
185 |
1609872,
17296934, 22151997 |
Invasion & Metastasis |
FLT1
mediates survival in post-EMT cancer cells |
58 |
115 |
14521839 |
Invasion & Metastasis |
IGF1R
->EMT |
51 |
68 |
19148466,
23994953 |
Invasion & Metastasis |
EDN->EMT |
81 |
143 |
19880243,
18718806 |
Invasion & Metastasis |
HGF->MET->EMT |
63 |
120 |
23474222,
23229794 |
Invasion & Metastasis |
PDGF
->EMT |
50 |
66 |
23261166,
23788982 |
Invasion & Metastasis |
Calveolin -| EMT in lipid rafts |
32 |
43 |
|
Invasion & Metastasis |
EGF->FOXM1/FOXOA |
111 |
225 |
|
Invasion & Metastasis |
EGF->EMT |
104 |
230 |
|
Invasion & Metastasis |
AR->PSA
in Prostate Cancer |
17 |
20 |
|
Invasion & Metastasis |
FoxM1
loop |
7 |
10 |
|
Invasion & Metastasis |
ECM->EMT |
126 |
256 |
|
Invasion & Metastasis |
CDH11
adherens junction |
16 |
24 |
22593800 |
Invasion & Metastasis |
PDGF-D->EMT |
85 |
172 |
23261166 |
Invasion & Metastasis |
F2
modulation of cytoskeleton |
100 |
172 |
|
Invasion & Metastasis |
F2
modulation of vascular permeability |
62 |
111 |
|
Invasion & Metastasis |
Coagulation
cascade in cancer |
63 |
73 |
23691951,11908507,11516455 |
Invasion & Metastasis |
UrokinaseR signaling |
45 |
74 |
|
Tumor
inflammation |
“Find
me” signals in apoptotic clearance |
90 |
111 |
19932201,
23284042, 22871044, 15928001, 22973558 |
Tumor
inflammation |
“Eat
me” signals in apoptotic clearance |
60 |
113 |
19932201,
22973558 |
Tumor
inflammation |
Transcellular
biosynthesis of eicosanoids |
28 |
26 |
1380800 |
Tumor
inflammation |
oxLDL->macrophage activation |
58 |
72 |
|
Tumor
inflammation |
Lymphotoxin B signaling |
38 |
64 |
20603617 |
Avoid
immune destruction |
OSM
signaling |
168 |
252 |
|
Avoid
immune destruction |
N1->N2 neutrophil polarization |
44 |
58 |
21798756 |
Avoid
immune destruction |
TANs
antitumor activity |
13 |
13 |
21798756 |
Avoid
immune destruction |
TENs
kill tumor cells |
36 |
44 |
21907922 |
Avoid
immune destruction |
M1->M2
macrophage polarization |
43 |
48 |
16269622 |
EMT: Epithelial-to-Mesenchymal Transition, LDL: Low-Density Lipoprotein, oxLDL: Oxidized LDL, EGFR: Epithelial Growth Factor, ROS: Reactive
Oxygen Species, HIF: Hypoxia-Induced Factor, ECM: Extracellular Matrix, F2: Thrombin,
TAMs: Tumor Associated Macrophages, TANs: Tumor Associated Neutrophils, TENs: Tumor
Entrained Neutrophils