ESR1 methylation status

All breast cancer cases

Methylated breast tumor

Unmethylated breast tumor

Body mass index
(BMI)

ER+PR+/
ER-PR-

ORc

95% CId

 

ER+PR+/                                 ER-PR-

OR

95% CI

 

ER+PR+/
ER-PR-

OR

95% CI

p for interaction

BMId (<25kg/m2)

86/37

1.00

reference

40/15

1.00

reference

46/22

1.00

reference

0.019

BMI (25-29.9kg/m2)

82/22

1.50

(0.81, 2.78)

39/8

1.79

(0.68, 4.70)

43/14

1.42

(0.64, 3.13)

BMI (≥30kg/m2)

78/19

1.74

(0.92, 3.28)

 

33/13

0.99

(0.41, 2.38)

 

45/6

3.76

(1.39, 10.15)

 

 

 

Supplemental Table 1: Age-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between postmenopausal body mass index (BMI) and ER+PR+ breast cancer (vs. ER-PR- breast cancer) considering ESR1 methylation status of the tumor (methylated vs. unmethylated), the Long Island Breast Cancer Study Project (1996-1997).