Table 2: Frequency of identified mutations and other findings.
|
Finding |
No. (%) |
|
TP53 |
31 (55) |
|
PIK3 |
19 (34) |
|
PTEN |
13 (23) |
|
ESR1 |
9 (16) |
|
RAD21 |
8 (14) |
|
CDKN |
7 (12.5) |
|
CHD1 |
7 (12.5) |
|
BRCA2 |
4 (7) |
|
GATA3 |
4 (7) |
|
TOP2A |
4 (7) |
|
FGF 3, 4, 19 |
3 (5.4) |
|
BRCA1 |
1 (1.8) |
|
ATM |
1 (1.8) |
|
MLH1 |
1 (1.8) |
|
MRE11A |
1 (1.8) |
|
MSH2 |
1 (1.8) |
|
RAD51D |
1 (1.8) |
|
Other |
34 (60) |
|
|
|
|
MSI-High |
4 (7) |
|
PD-L1 (≥ 1%) |
15 (27) |
|
TMB (≥ 10 mutations/megabase) |
3 (5.4) |
MSI: Microsatellite Instability; TMB: Tumor Mutational Burden.