Outcome

Study results and measurements

Absolute Effect Estimates

Certainty in effect estimates (quality

of evidence)

NMBAs

No NMBAs

All-cause mortality

^aRR 0.84

(0.74 to 0.95)

Based on data from 3,351 patients in six studies

603/1691 (35.7%)

673/1660 (40.5%)

Moderate due to serious inconsistency

5 fewer per 1,000 (from 105 fewer to 20 fewer)

Health-related quality of life by EQ-5D-5L

^bMD 0.02 lower
(0.09 lower to 0.05 higher)

Based on data from 246 patients in one study

127

119

Low due to very serious imprecision

Adverse events

^aRR 0.80
(0.60 to 1.08)

Based on data from 4,627 patients in four studies

265/2333 (11.4%)

270/2294 (11.8%)

Low due to serious imprecision and inconsistency

24 fewer per 1000
(from 47 fewer to 9 more)

Organ failure free days to day 28 by system

^bMD 1.65 higher
(1.97 lower to 5.27 higher) Based on data from 5,315 patients in two studies

657

641

Very low due to very serious imprecision and inconsistency

Improvement PaO2/FiO2

^bMD 11.02 higher
(5.38 lower to 16.66 higher) Based on data from 3,637 patients in four studies

1900

1737

Low due to serious imprecision

Days free of ventilation at 28 days

^bMD 0.67 higher
(0.5 lower to 1.85 higher) Based on data from 1,461 patients in five studies

737

724

Low due to very serious imprecision

Days not in the hospital

^bMD 0.15 higher
(0.99 lower to 1.3 higher) Based on data from 2,714 patients in three studies

127

119

Very low due to serious inconsistency and very serious imprecision