Table 1: Demographic table.
|
Author & year |
Sample Size |
Follow up |
Location |
ARDS definition |
Intervention |
Ventilation strategy |
Risk of bias |
||
|
Low |
Unclear |
High |
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|
Gainnier, 2004 [11] |
56 patients |
ICU discharge |
France four ICUs |
American-European consensus definition. (PaO2/FiO2 ratio < 150) |
A cisatracurium bolus of 0.2 mg/kg followed by an infusion at a rate of 5 g/kg/min vs. saline at 4 mL/h |
VAC 6-8 ml PBW. PEEP by ARDs network. NO allowed. Prone position if PaO2/FiO2 was < 60 mmHg for 30 min. |
71.4% |
28.57% |
0% |
|
Forel, 2006 [12] |
36 patients |
ICU discharge |
France three ICUs |
American-European consensus definition. (PaO2/FiO2 ratio < 200) |
A cisatracurium bolus of 0.2 mg/kg followed by an infusion at a rate of 5 g/kg/min vs. saline at 4 mL/h |
VAC 4 -8 mL PBW. Plateau pressure < 30 mmHg. PEEP by ARDs network |
71.4% |
28.57% |
0% |
|
Papazian, 2010 [13] |
339 patients |
90 days |
France 20 ICUs |
American-European consensus definition. (PaO2/FiO2 ratio < 150) |
A bolus of 15 mg cisatracurium followed by 37.5 mg per hour for 48 hours vs. placebo. |
VAC 6-8 mL PBW. Prone position. Inhaled NO. Almitrinebismesylate. Open label cisatracurium. |
100% |
0% |
0% |
|
Lyu, 2014 [14] |
96 patients |
21 days |
China one ICU |
The Berlin definition. (PaO2/FiO2 ratio < 150) |
A bolus of 0.1 mg/k vecuronium followed by 0.05 mg/kg/h for 24-48 h. Usual treatment for control group. |
VAC 6-8 ml/kg PBW. Plateau pressure < 35 cmH2O. PEEP according to the best oxygenation PEEP method. |
57.14% |
42.85% |
0% |
|
Guervilly, 2017 [15] |
30 patients |
ICU discharge |
France two ICUs |
The Berlin definition. (PaO2/FiO2 ratio < 150) |
A bolus of 15 mg cisatracurium followed by 37.5 mg per hour for 48 hours. Usual treatment for control group. |
VAC 6 mL PBW according to the original ARDS net protocol. |
57.14% |
42.85% |
0% |
|
Moss, 2019 [19] |
1008 patients |
12 months |
USA 13 ICUs |
The Berlin definition. (PaO2/FiO2 ratio < 150) |
A bolus of 15 mg cisatracurium followed by 37.5 mg per hour for 48 hours with concomitant deep sedation. Usual care without routine neuromuscular blockade and with lighter sedation targets. |
Low tidal volume ventilation within 2 hours after randomization and a high PEEP strategy for up to 5 days after randomization |
57.14% |
0% |
42.85% |
|
ICU: Intensive care unit; VAC: Volume assist control; PEEP: Positive end respiratory pressure. |
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