Table 1: Study characteristics of preclinical studies.

Clinical measure Studies
No. of publications 76
No. of treatment arms 101
Source of stem cell
• Rat 30
• Human 40
• Mouse 6
• Porcine 1
Species receiving stem cell
• Rat 71
• Mouse 4
• Both 1
Route of administration*
• IA 34
• IV 13
• IC 33
• IT 1
Range of stem cell doses 1500-20000000
Time of administration
• 0-14 h 21
• 24 h 26
• > 24 h to 1 wk 26
• > 1 wk to 30 d 5
Stem cell immunogenicity
• Autologous 7
• Allogeneic 26
• Xenogeneic 44
Outcome measure
• Behavioural 23
• Histologic 6
• Both 47
Artery occlusion
• Permanent 24
• Transient 52

*Route of administration: IA: Intra-arterial; IV: Intravenous; IC: Intracerebral; IT: Intrathecal.