Table 1: Study characteristics of preclinical studies.
Clinical measure | Studies |
No. of publications | 76 |
No. of treatment arms | 101 |
Source of stem cell | |
• Rat | 30 |
• Human | 40 |
• Mouse | 6 |
• Porcine | 1 |
Species receiving stem cell | |
• Rat | 71 |
• Mouse | 4 |
• Both | 1 |
Route of administration* | |
• IA | 34 |
• IV | 13 |
• IC | 33 |
• IT | 1 |
Range of stem cell doses | 1500-20000000 |
Time of administration | |
• 0-14 h | 21 |
• 24 h | 26 |
• > 24 h to 1 wk | 26 |
• > 1 wk to 30 d | 5 |
Stem cell immunogenicity | |
• Autologous | 7 |
• Allogeneic | 26 |
• Xenogeneic | 44 |
Outcome measure | |
• Behavioural | 23 |
• Histologic | 6 |
• Both | 47 |
Artery occlusion | |
• Permanent | 24 |
• Transient | 52 |
*Route of administration: IA: Intra-arterial; IV: Intravenous; IC: Intracerebral; IT: Intrathecal.