Table 1:Recommended antimicrobial therapy classified by pathogens of necrotizing soft tissue infection [4,20,21].
| Pathogens | Recommended antimicrobial agents | |
|---|---|---|
| Empiric therapy | Gram positive organisms including Staphylococcus aureus and Streptococcus spp. | Vancomycin, linezolid, daptomycin for resistant Gram positive organisms |
| Gram negative bacilli including Enterobacteriaceae and Pseudomonas aeruginosa | Anti-pseudomonal agents* such as piperacillin/tazobactam, cefepime, meropenem or other carbapenems | |
| Anaerobes including Bacteroides spp. | Combination of β-lactams and β-lactamase Inhibitors such as piperacillin/tazobactam, and ampicillin/sulbactam or carbapenems such as meropenem, or metronidazole |
|
| For suppression of the toxin production | Clindamycin | |
| Definitive therapy | Clostridium spp. | Penicillin and clindamycin |