Table 1: Shows the summarised findings of 3 different patient cohorts with severe Covid-19 induced ARDS who received added cotrimoxazole (CTX) or trimethoprim (TMP) added to standard care (ST) versus ST-alone. The table shows the mortality and mechanical ventilation rate relative to standard care with the 4th cohort of 15 home treated Covid-19 ARDS patients supplied with oxygen and CTX and their outcome..

Table 1: Shows the summarised findings of 3 different patient cohorts with severe Covid-19 induced ARDS who received added cotrimoxazole (CTX) or trimethoprim (TMP) added to standard care (ST) versus ST-alone. The table shows the mortality and mechanical ventilation rate relative to standard care with the 4th cohort of 15 home treated Covid-19 ARDS patients supplied with oxygen and CTX and their outcome.

Author (reference No.)	Randomised	No. ST ^*	*No. ST ^ + CTX or TMP**	Added Steroids	Mortality ST	Mortality CTX (p value vs. ST)	Mechanical Ventilation ST	Mechanical Ventilation (p value vs. ST)
Quadery [75]	Yes	55	58 ∆	100%	29%	11% (p = 0.020)	13%	9% (p = 0.90)
Singh [76]	No	50	151 ∆	100%	40%	13% (p = 0.001)	40%	15% (p = 0.001)
Siddiqui [77]	No	0	15 ∆	Nil	-	0%	-	0%
Varney [67]	No	84	46 ϑ	ST = 73% TMP = 32%	36%	17% (p = 0.014)	7%	4% (p = 0.9)

*ST: Standard Therapy of broad spectrum antibiotics, heparin, oxygen: ∆CTX (cotrimoxazole 960 mg) 8 hrly: ϑTMP (trimethoprim) 400 mg/day in place of CTX