| Physical Finding | Associated cardiac condition(s) |
| Early Systolic Clicks (Ejection Sounds) | |
| High frequency systolic ejection clicks, 0.09 to 0.14 seconds after first heart sound (S1) | Aortic stenosis (bicuspid aortic valve), pulmonary stenosis, pulmonary hypertension, dilated pulmonary artery, left ventricular outflow obstruction |
| Midsystolic Clicks (Nonejection sounds) | |
| Medium-to-high frequency clicks, 0.17 to 0.27 seconds after S1 | Mitral valve prolapse (& associated late systolic murmur), tricuspid valve prolapse, nonmyxomatous mitral valve disease, adhesive pericarditis, atrial myxoma, atrial septal aneurysms, left ventricular aneurysm |
| Early Diastolic Opening Snap (OS) | |
| High-frequency sound, 0.04 to 0.12 seconds after second heart sound (S2) | Mitral stenosis, tricuspid stenosis |
| Early-Mid Diastolic Tumor Plops | |
| Low frequency sound, 0.04 to 0.12 seconds after S2 | Atrial myxoma |
| Early-Mid Diastolic Pericardial Knocks | |
| Pericardial knock, 0.06 to 0.14 seconds after S2 | Constrictive pericarditis |