| Physical Finding | Associated cardiac condition(s) |
| Head & Neck | |
| De Musset sign (head bobbing) | Aortic regurgitation |
| Hoarseness | Pericardial effusion, thoracic aneurysm |
| Hiccups | Pericardial effusion (phrenic nerve stimulation) |
| Eyes | |
| Dislocated lens / ectopialentis (Marfan’s syndrome) | Aortic regurgitation, mitral valve prolapse |
| Blue Sclera, brittle bones (Osteogenesisimperfecta) | Mitral valve prolapse, aortic dilation/regurgitation and dissection |
| Bilateral forward displacement of eyeballs (Graves' ophthalmopathy) | Tachycardia, atrial fibrillation, high output heart failure |
| Systolic pulsation | Severe tricuspid regurgitation |
| Chest | |
| Pectusexcavatum, straight/ flat thoracic spine (Straight-back syndrome, ankylosing spondylitis) | Mitral valve prolapse syndrome, aortic regurgitation |
| Hands & Legs | |
| Unilateral digital clubbing | Aortic aneurysm (interferes with blood supply to one arm), brachial arteriovenous fistula, arterial graft sepsis, & hemiplegic stroke |
| Bilateral digital clubbing | Cyanotic congenital heart disease, neoplastic & suppurative intrathoracic disease, diffuse pulmonary disease, infective endocarditis, inflammatory bowel disease, celiac disease, cirrhosis, thyroid acropachy (extreme autoimmune thyroid disease) |
| Ulnar deviation, "swan neck" (rheumatoid arthritis) | Aortic regurgitation, mitral regurgitation, pericarditis, cardiomyopathy |
| Arachnodactyly "spider fingers" long and slender digits (Marfan’s syndrome) | Aortic regurgitation, mitral valve prolapse |
| Xanthoma | Hypercholesterolemia |
| Systolic blush & diastolic blanch when upward traction on the fingernail (Quincke's pulse) | Aortic regurgitation |
| Thumb with extra phalanx (Holt-Oram syndrome) | Atrial septal defect |
| Petechiae | Infective endocarditis, trauma |
| Painless hemorrhagic lesions on palms or soles (Janeway lesions) | Infective endocarditis |
| Small tender erythematous skin lesions on pads of the fingers, toes, palms or soles (Osler nodes) | Infective endocarditis |
| Triphasic (white, blue, red) change of finger color in cool temperatures or emotional stress | Raynaud’s phenomenon |
| Bilateral peripheral edema | Excess extracellular fluid (5 liters or more): heart failure, constrictive pericarditis |
| Unilateral peripheral edema | Venous obstruction/damage/removal, hemiplegia (on paralyzed side) |