Sample description of the SUCCESS-A study variables considered by the PRIM algorithm, including the BRCA1-defined cluster id. Patients were randomized to either standard of care (arm AB) or standard of care plus Gemcitabine (arm AA).

Table 2: Sample description of the SUCCESS-A study variables considered by the PRIM algorithm, including the BRCA1-defined cluster id. Patients were randomized to either standard of care (arm AB) or standard of care plus Gemcitabine (arm AA).

Variable

Treatment

AA (n = 1590)

AB (n = 1624)

P-value

ER status

Positive

Negative

1086 (0.68)

504 (0.32)

1132 (0.70)

492 (0.30)

0.411

HER2 status

Positive

Negative

509 (0.32)

1081 (0.68)

484 (0.30)

1140 (0.70)

0.188

PR status

Positive

Negative

1003 (0.63)

587 (0.37)

1046 (0.64)

578 (0.36)

0.456

Menopause status

Premenopausal

Postmenopausal

667 (0.42)

923 (0.58)

653 (0.40)

971 (0.60)

0.334

Grade

G1 (well differentiated)

G2 (moderately differentiated)

G3 (poorly differentiated)

81 (0.05)

763 (0.48)

746 (0.47)

68 (0.04)

778 (0.48)

0.451

T stage

pT0

pT1

pT2

pT3

pT4

1 (0.00)

657 (0.41)

830 (0.52)

81 (0.05)

21 (0.01)

0 (0.00)

672 (0.41)

838 (0.52)

90 (0.06)

24 (0.01)

0.823

N stage

pN0

pN1

pN2

pN3

570 (0.36)

697 (0.44)

229 (0.14)

94 (0.06)

561 (0.35)

747 (0.46)

213 (0.13)

103 (0.06)

0.487

Tumor type

Invasive ductal

Invasive lobular

Other invasive epithelial breast cancer

1252 (0.79)

165 (0.10)

173 (0.11)

1278 (0.79)

175 (0.11)

171 (0.11)

0.899

Age categorized

(-Inf,50]

(50,65]

(65, Inf]

654 (0.41)

693 (0.44)

243 (0.15)

639 (0.39)

727 (0.45)

258 (0.16)

0.583

BMI categorized

(-Inf,25]

(25,30]

(30, Inf]

739 (0.46)

537 (0.34)

314 (0.20)

771 (0.47)

513 (0.32)

340 (0.21)

0.387

CLUSTER ID

144 (0.09)

150 (0.09)

353 (0.22)

139 (0.09)

156 (0.10)

169 (0.11)

254 (0.16)

155 (0.10)

70 (0.04)

159 (0.10)

123 (0.08)

345 (0.21)

142 (0.09)

185 (0.11)

161 (0.10)

265 (0.16)

172 (0.11)

72 (0.04)

0.538