Table 5: Simulation results when true hazard ratio = 0.7.

Control median

Sample size

Percent censored

Bias

ASE

ESD

Proportion of HR

< 0.5

< 0.4

< 0.3

6

800

10.9

0.0007

0.0755

0.0746

0.0000

0.0000

0.0000

600

10.9

-0.0010

0.0872

0.0880

0.0002

0.0000

0.0000

400

10.9

-0.0006

0.1069

0.1050

0.0006

0.0000

0.0000

200

10.9

0.0008

0.1516

0.1515

0.0152

0.0000

0.0000

100

11.0

-0.0057

0.2155

0.2189

0.0656

0.0054

0.0002

50

11.0

-0.0143

0.3078

0.3170

0.1514

0.0422

0.0062

12

800

31.9

0.0004

0.0863

0.0880

0.0000

0.0000

0.0000

600

31.9

-0.0003

0.0997

0.1004

0.0002

0.0000

0.0000

400

32.0

0.0015

0.1222

0.1200

0.0022

0.0000

0.0000

200

31.9

-0.0004

0.1732

0.1722

0.0244

0.0012

0.0000

100

32.0

-0.0053

0.2461

0.2436

0.0874

0.0136

0.0006

50

32.2

-0.0100

0.3518

0.3592

0.1784

0.0644

0.0088

24

800

56.0

-0.0018

0.1078

0.1068

0.0018

0.0000

0.0000

600

56.0

-0.0035

0.1245

0.1249

0.0042

0.0000

0.0000

400

56.1

-0.0023

0.1528

0.1539

0.0166

0.0002

0.0000

200

56.0

-0.0016

0.2166

0.2151

0.0622

0.0058

0.0000

100

56.2

-0.0105

0.3095

0.3084

0.1436

0.0408

0.0056

50

56.4

-0.0138

0.4466

0.4621

0.2320

0.1110

0.0402

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Median HR rounded to two decimal places was 0.70 in all cases except for two cases when it was 0.69 (Control median = 6, Sample size = 100 and Control median = 24, Sample size = 0).