Table 2: Simulation results when true hazard ratio = 1.

Control median

Sample size

Percent censored

Bias

ASE

ESD

Proportion of HR

< 0.5

< 0.4

< 0.3

6

800

6.8

0.0009

0.0733

0.0733

0.0000

0.0000

0.0000

600

6.7

0.0011

0.0847

0.0864

0.0000

0.0000

0.0000

400

6.8

-0.0021

0.1038

0.1067

0.0000

0.0000

0.0000

200

6.8

0.0009

0.1473

0.1484

0.0000

0.0000

0.0000

100

6.8

-0.0007

0.2092

0.2124

0.0004

0.0000

0.0000

50

6.9

0.0031

0.2991

0.3049

0.0112

0.0018

0.0000

12

800

25.5

0.0018

0.0820

0.0835

0.0000

0.0000

0.0000

600

25.6

-0.0015

0.0948

0.0949

0.0000

0.0000

0.0000

400

25.5

0.0018

0.1160

0.1165

0.0000

0.0000

0.0000

200

25.6

-0.0053

0.1646

0.1661

0.0002

0.0000

0.0000

100

25.7

0.0028

0.2338

0.2360

0.0022

0.0002

0.0000

50

26.0

-0.0099

0.3341

0.3357

0.0198

0.0036

0.0002

24

800

50.3

0.0013

0.1005

0.1017

0.0000

0.0000

0.0000

600

50.3

0.0012

0.1160

0.1168

0.0000

0.0000

0.0000

400

50.3

0.0031

0.1422

0.1421

0.0000

0.0000

0.0000

200

50.4

-0.0015

0.2019

0.2006

0.0008

0.0000

0.0000

100

50.4

-0.0035

0.2875

0.2902

0.0112

0.0020

0.0000

50

50.8

-0.0062

0.4136

0.4207

0.0520

0.0162

0.0030

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Median HR rounded to two decimal places was 1.00 in all cases except for two cases when it was 0.99 (Control median = 12, Sample size = 200 and Control median = 12, Sample size = 50).