Table 2: SNPs within the PTPRN2 gene associated with risk and age at onset of cancer using PLINK (p < 0.05)

SNP	Position^a	Allele^b	MAF^c	HWE^d	OR-Cancer^e	p-Cancer^f	EMP^g	β-AAO^h	p-AAO^i	EMP^j
rs7783909	157287177	A	0.15	0.413	1.42(1.1-1.83)	6.52E-03	4.0E-03	-0.017	0.0713	0.0739
rs4909140	157721662	G	0.46	0.727	1.16(1.03-1.31)	1.57E-02	1.1E-02	-0.017	6.18E-04	4.0E-03
rs10244830	157674626	T	0.35	0.318	0.84(0.73-0.97)	1.81E-02	1.4E-02	0.002	0.7115	0.699
rs7795387	157764272	G	0.22	0.409	0.74(0.57-0.96)	2.23E-02	2.2E-02	0.002	0.844	0.856
rs6970487	157712908	G	0.42	0.561	0.86(0.76-0.98)	2.55E-02	2.8E-02	0.01	0.0653	0.0579
rs4595081	157700684	T	0.42	0.475	0.86(0.76-0.98)	2.69E-02	2.9E-02	0.01	0.065	0.058
rs6944416	157708321	G	0.42	0.623	0.86(0.76-0.98)	2.78E-02	3.0E-02	0.01	0.064	0.06
rs17837789	157128182	G	0.15	0.186	0.63(0.41-0.96)	3.29E-02	2.8E-02	-0.027	0.159	0.155
rs920023	157427075	G	0.24	0.768	0.8(0.65-0.99)	4.03E-02	3.9E-02	0.016	0.0751	0.0739
rs4909289	157647665	A	0.26	0.82	0.82(0.68-0.99)	4.85E-02	4.3E-02	0.003	0.699	0.687
rs1670340	157963783	C	0.49	0.385	0.97(0.86-1.1)	0.654	0.687	-0.016	1.69E-03	2.0E-03
rs1630862	157961357	G	0.45	0.965	0.97(0.86-1.09)	0.588	0.598	-0.013	1.17E-02	0.012
rs11760246	157523437	T	0.37	0.016	1.04(0.91-1.19)	0.529	0.54	0.013	1.81E-02	0.025
rs1268391	157111665	C	0.32	0.841	0.96(0.83-1.12)	0.606	0.62	-0.015	2.16E-02	0.023
rs7777448	157724510	A	0.39	0.99	0.98(0.86-1.12)	0.736	0.712	-0.013	2.38E-02	0.034
rs3752374	157581981	G	0.05	0.662	1.73(0.73-4.11)	0.239	0.155	-0.07	3.29E-02	0.04
rs10949670	157388704	T	0.39	0.142	1.0(0.88-1.14)	0.956	0.95	0.011	3.95E-02	0.043
rs12698149	rs12698149	T	0.39	0.238	1.05(0.92-1.19)	0.494	0.504	0.011	3.95E-02	0.045

^a Physical position(bp); ^b Minor allele; ^c Minor allele frequency; ^d Hardy-Weinberg equilibrium test p-value;

^e Odds ratio for the risk of cancer based on logistic regression using PLINK; ^f p-value for the risk of cancer based on logistic regression;

^g empirical p-value for the risk of cancer generated by 100,000 permutation tests using Max (T) permutation procedure implemented in PLINK;

^h Regression coefficient for AAO of cancer based on linear regression using PLINK; ⁱ p-value for AAO of cancer based on linear regression ;

^j empirical p-value for AAO of cancer generated by 100,000 permutation tests using Max (T) permutation procedure implemented in PLINK.