Table 3: Parameter estimates for annual rate of change for all neuropsychological tests

Domain

Test

Did not progress

to MCI

Progress to MCI

Difference

Estimate

(SE)

 

p-value

Estimate

(SE)

 

p-value

Estimate

(SE)

 

p-value

Memory

MMSE

-0.02 (0.03)

0.390

-0.06

(0.03)

0.027

0.04

(0.04)

0.343

Logical Memory:

0.04

 

0.202

-0.04

0.140

0.08

0.052

Immediate

(0.03)

 

(0.03)

 

(0.04)

 

Logical Memory:

0.06

0.035

-0.02

0.404

0.08

0.038

Delayed

(0.03)

 

(0.03)

 

(0.04)

 

Factor CFM

0.04

(0.03)

0.202

-0.04

(0.03)

0.148

0.08

(0.04)

0.037

Factor DFM

0.05

(0.04)

0.253

-0.09

(0.04)

0.026

0.14

(0.06)

0.020

Attention-Psychomotor Speed

Digits Forward

-0.04

(0.02)

0.127

-0.03

(0.02)

0.268

-0.01

(0.03)

0.770

Digits Backward

0.01

(0.03)

0.680

-0.03

(0.03)

0.201

0.04

(0.04)

0.231

WAIS

-0.03

(0.02)

0.073

-0.03

(0.02)

0.124

0.01

(0.02)

0.839

TRAILS A

0.03

(0.03)

0.196

-0.01

(0.03)

0.599

0.05

(0.04)

0.199

TRAILS B

0.01

(0.02)

0.742

-0.05

(0.02)

0.039

0.03

(0.03)

0.089

Factor CFM

0.00

(0.02)

0.852

-0.04

(0.02)

0.001

0.04

(0.02)

0.048

Factor DFM

-0.00

(0.03)

0.914

-0.08

(0.03)

0.003

0.04

(0.04)

0.046

Language

Animals

-0.00

(0.02)

0.847

-0.04

(0.02)

0.056

0.04

(0.03)

0.222

Vegetables

-0.02

(0.02)

0.493

-0.05

(0.03)

0.029

0.04

(0.04)

0.285

Boston Naming Test

0.04

(0.03)

0.100

-0.02

(0.03)

0.285

0.06

0.076

Factor CFM

-0.00

(0.02)

0.916

-0.04

(0.02)

0.014

0.04

(0.03)

0.094

Factor DFM

-0.02

(0.03)

0.515

-0.09

(0.03)

0.001

0.07

(0.04)

0.069

Total

Factor CFM

0.05

(0.02)

0.058

-0.04

(0.02)

0.098

0.09

(0.03)

0.012

Factor DFM

0.01

(0.03)

0.654

-0.12

(0.03)

<.001

0.13

(0.05)

0.004