Table 3: Logistic regression multivariate analysis for CN-MDS. CN-MDS patients with mutations in histone modifier genes and signaling genes have 20- and 48-fold higher odds, respectively, of transforming to AML than patients without these mutations; whereas sex, age, treatment regimen, and transplant history are not significant contributing factors.
Variable |
Number |
Odds ratio to AML transformation (95% CI) |
p-value |
Sex |
|
|
|
Male |
38 |
Referent |
|
Female |
20 |
0.86 (0.07-9.62) |
0.899 |
Age |
|
0.94 (0.82-1.07) |
0.326 |
Treatment |
|
|
|
Non-hypomethylation |
9 |
Referent |
|
Hypomethylation |
49 |
1.31 (0.14-12.27) |
0.807 |
Transplant |
|
|
|
No |
38 |
Referent |
|
Yes |
19 |
0.64 (0.06-6.87) |
0.713 |
Histone modifier genes mutation |
|
|
|
No |
41 |
Referent |
|
Yes |
17 |
19.75 (1.82-213.21) |
0.014 |
Signaling genes mutation |
|
|
|
No |
44 |
Referent |
|
Yes |
14 |
47.77 (3.18-718.10) |
0.005 |