Table 3: Logistic regression multivariate analysis for CN-MDS. CN-MDS patients with mutations in histone modifier genes and signaling genes have 20- and 48-fold higher odds, respectively, of transforming to AML than patients without these mutations; whereas sex, age, treatment regimen, and transplant history are not significant contributing factors.

Variable

Number

Odds ratio to AML transformation (95% CI)

p-value

Sex

 

 

 

 Male

38

Referent

 

 Female

20

0.86 (0.07-9.62)

0.899

Age

 

0.94 (0.82-1.07)

0.326

Treatment

 

 

 

 Non-hypomethylation

9

Referent

 

 Hypomethylation

49

1.31 (0.14-12.27)

0.807

Transplant

 

 

 

 No

38

Referent

 

 Yes

19

0.64 (0.06-6.87)

0.713

Histone modifier genes mutation

 

 

 

 No

41

Referent

 

 Yes

17

19.75 (1.82-213.21)

0.014

Signaling genes mutation

 

 

 

 No

44

Referent

 

 Yes

14

47.77 (3.18-718.10)

0.005