MiRNAs down-regulated in GBM | Number of profiling studies* | Cellular Functions | Validated targets in GBM | References |
miR-128^ | 8 | Proliferation, self -renewal, cell cycle | ARP5, Bmi1, E2F3A, EGFR, PDGFRA, WEE1 | [31,128,131,132] |
Angiogenesis | p70S6K1 | [133] | ||
miR-218 | 5 | Migration/invasiveness | IKK-β, LEF1 | [122,125] |
Apoptosis | ECOP | [129] | ||
miR-132 | 5 | NA | NA | - |
miR-7 | 4 | Proliferation | EGFR, IRS1, IRS2 | [72] |
Invasiveness | FAK | [127] | ||
miR-124 | 3 | Migration/invasiveness | IQGAP1, LAMC1, ITGB1 | [120] |
Cell cycle/proliferation | CDK6, pRB, CDK4, | [47,119] | ||
miR-323 | 3 | NA | NA | - |
miR-221 | 4 | Cell cycle | p27/KIP1, p57/KIP2 | [80,82]† |
Apoptosis | NIAP, PUMA | [81,83]† | ||
Invasiveness | PTPμ | [78]† | ||
miR-181b | 3 | Proliferation/invasivenes | IGF1R | [124] |
miR-222 | 3 | Cell cycle | p27/KIP1, p57/KIP2 | [80,82]† |
Apoptosis | NIAP, PUMA | [81,83]† | ||
Invasiveness | PTPμ | [78]† | ||
miR-31 | 3 | Migration/Invasiveness | RDX | [130] |
miR-138 | 3 | Proliferation | Msi1 | [126] |
miR-181c | 3 | NA | NA | - |
miR-379 | 3 | NA | NA | - |