Table 1: Studies of high-moderate quality on the use of partially hydrolyzed formulas for the prevention of atopic dermatitis.
| Reference | Design of study | Population study | Breastfeeding | Supplementary feeding |
|
Randomized Double-blind |
2 AF - PHWP n 28 - CF n 30 |
No |
0-4 m: formula 4 m: grated apple > 6 m: diversification without limitations |
|
Marini [21] |
Randomized Double-blind |
2 AF - PHWP n 41 - CF n 43 |
Yes |
0-5 m: BF ± formula 5-12 m: hypoallergenic foods > 12 m: unrestricted diet |
Chan [23] |
Randomized |
1 AF - PHWP n 53 - CF n 57 |
No |
0-4 m: formula > 4 m: diversification without limitations |
Von Berg [24] |
Randomized Double-blind |
1 AF - PHWP n 241 - CF n 256 |
Yes |
0-4 m: formula > 4 m: diversification without limitations |
AF: First-Degree Family History of Atopy; PHWP: Partially Hydrolyzed Whey Protein; CF: Conventional Formula; BF: BreastFeeding.