Table 2: Clark classification of allergic adverse reactions.

Grade	Clinical manifestations
1. Mild	Localized skin lesions (hives, rash, angioedema or oral pruritus)
2. Mild	Generalized skin reactions
3. Mild	Grade 1 or 2 associating rhinoconjunctivitis or gastrointestinal symptoms
4. Moderate	Difficulty breathing
5. Severe	Severe respiratory distress or systemic symptoms (hypotension, loss of consciousness)