Table 1: Patients and intervention characteristics.

Author/year Study Enrollment Setting HFOV group CMV group ARDS Enrollment characteristics HFOV settings
Number Age
(mean)
Number Age
(mean)
PaO2/FiO2 Oxy. Index Vent. Days prior study APACHE II
(score)
Mean Pr. Mean Freq. Amplitude
Young, 2013 [17] RCT 2007-2012 ICU in 29 centers 398 54.9 397 55.9 113 ± 38 NM 2.2 ± 2.2 21.8 ± 6.1 5 10 100 (Cycle volume)
Derdak [14] RCT 1997-2000 ICU in 13 centers 75 50 73 51 112 24 3.5 22 5 5 chest wall-mid thigh vibration
Bollen [29] RCT 1997-2001 ICU in 5 centers 37 81.7 24 81.7 NA 22 2.1 21 5 5 according to PaCO2
Demory [20] RCT 2003-2004 ICU in 1 center 13 45 15 52 122 NM NM NM 5 5 NM
Ferguson [15] RCT 2007-2012 ICU in 39 centers 275 54.5 273 54 117.5 NM 2.2 29 30 3-12Hz 90
Mentzelopoulos [18] RCT 2006-2009 ICU in 1 center 61 52 64 52.9 NM NM NM NM NM 4.1 NM
Papazian [37] RCT NM ICU in 1 center 13 51 13 51 103 19.2 NM NM 5 5 110
Shah [19] RCT NM ICU in 1 center 15 49 13 49.2 110.6 NM 1.9 19 5 5 chest wall-mid thigh vibration
Fort [35] Cohort NM ICU in 1 center 17 38 NA NA 69 49 5.1 23 28.4 5.2 65.1
Claridge [22] Cohort 1998-1999 ICU in 1 center 5 37 NA NA 52 52 1.4 28 4-8 cm H2O 4 NM
Mehta [26] Cohort 1997-1999 ICU in 1 center 24 48 NA NA 99 32 5.7 22 5 5 Chest wall-mid thigh vibration
Anderson 2002 Retrospective 1997-2001 ICU in 1 center 16 38 NA NA 92 28 7.2 NM 23.7 4.6 64.9
David [23] Cohort 1998-2001 ICU in 1 center 42 49 NA NA 94 23 3 28 NM 5 NM
Cartotto [21] Retrospective 1999-2002 ICU in 1 center 25 44 NA NA NM NM 4.8 17 33 4.5 NM
Mehta [26] Retrospective 1998-2002 ICUs in 3 centers 156 48 NA NA 91 31 5.6 24 NM NM NM
Ferguson 2005 Cohort NM 4 ICU in 4 centers 25 50 NA NA 121 26 0.5 24 22 5 71
Pachl [38] Cohort NM ICU in 1 center 30 55 NA NA 121 26 7.7 NM NM 5 NM
Finkielman [24] Retrospective 2003-2004 ICU in 1 center 14 56 NA NA 73 35 1.7 35 19 5.3 64
Friesecke [25] Cohort 2010-2014 ICU in 1 center 26 63 NA NA 139 NM 0.65 NM 19 5 NM
Mentzelopoulos [27] RCT NM ICU in 1 center 14 18-75 NA NA 96.8 NM NM NM NM NM NM