Table 4: Quantitative results: secondary
endpoints
|
Endpoint |
Group 1 Pre-HFC |
Group 2 HFC-treated |
||||||||
|
N |
Mean |
Median |
SD |
Range |
N |
Mean |
Median |
SD |
Range |
|
|
Total factor VII (mcg/kg) |
49 |
18 |
0 |
45 |
0-183 |
50 |
20 |
0 |
57 |
0-280 |
|
Intubation (hours) |
49 |
69 |
73 |
54 |
0-192 |
50 |
71 |
38 |
108 |
0-597 |
|
LOS ICU (days) |
49 |
15 |
11 |
13 |
1-62 |
50 |
15 |
8.0 |
28 |
1-190 |
|
LOS hospital (days) |
49 |
18 |
12 |
18 |
1-104 |
50 |
16 |
9.0 |
28 |
1-190 |
|
Preop
PT (sec) |
8 |
14.8 |
14.3 |
2 |
12.5-17.6 |
5 |
19.6 |
15.8 |
7.0 |
13.6-30.7 |
|
Preop
INR |
8 |
1.1 |
1.1 |
0.2 |
0.89-1.38 |
5 |
1.6 |
1.2 |
0.8 |
1.0-2.8 |
|
Preop
PTT (sec) |
9 |
41.2 |
35 |
15 |
30.9-75.1 |
5 |
40.5 |
38 |
7.1 |
36.2-53.1 |
|
Postop PT (sec) |
46 |
19.3 |
19.4 |
3 |
12-27.8 |
49 |
22.4 |
20.6 |
9.2 |
13.4-80.3 |
|
Postop INR |
46 |
1.56 |
1.57 |
0.32 |
0.84-2.5 |
49 |
1.93 |
1.70 |
1.2 |
0.98-9.7 |
|
Postop PTT (sec) |
46 |
53 |
51 |
17 |
26.6-107 |
49 |
62 |
49 |
36 |
31.7-200 |
|
Preop
fibrinogen (mg/dL) |
NA |
NA |
NA |
NA |
NA |
35 |
225 |
224 |
61 |
100-350 |
|
Rewarming fibrinogen (mg/dL) |
NA |
NA |
NA |
NA |
NA |
34 |
114 |
115 |
42 |
50-245 |
Bold values denote p < 0.05 vs. Group 1; HFC: Human
Fibrinogen Concentrate; ICU: Intensive Care Unit; INR: International Normalized
Ratio; LOS: Length of Stay; PT: Prothrombin Time; PTT:
Partial Thromboplastin Time