Table 1: Chemical and physical properties of the three considered long-acting local anesthetics.
|
|
Bupivacaine |
Ropivacaine |
Levobupivacaine |
|
Molecular weight |
288 |
274 |
288 |
|
pKa |
8.1 |
8.1 |
8.1 |
|
Liposolubility |
30 |
2.8 |
30 |
|
Partition coefficient |
28 |
9 |
28 |
|
Protein binding (%) |
95 |
94 |
95 |