Table 2: American joint committee on cancer TMN classification for penile cancer.
|Primary Tumor (T)|
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
Tis Carcinoma in situ
Ta Noninvasive verrucous carcinoma*
T1a Tumor invades subepithelial connective tissue without lymph vascular invasion and is not poorly differentiated (i.e., grade 3-4)
T1b Tumor invades subepithelial connective tissue with lymph vascular invasion and is poorly differentiated
T2 Tumor invades corpus spongiosum or cavernosum
T3 Tumor invades urethra
T4 Tumor invades other adjacent structures
*Note: Broad pushing penetration (invasion) is permitted; destructive invasion is against this diagnosis.
Regional Lymph Nodes (N)
Clinical Stage Definition*
cNX Regional lymph nodes cannot be assessed
cN0 No palpable or visibly enlarged inguinal lymph nodes
cN1 Palpable mobile unilateral inguinal lymph node
cN2 Palpable mobile multiple or bilateral inguinal lymph nodes
cN3 Palpable fixed inguinal lymph nodal mass or pelvic lymphadenopathy unilateral or bilateral
*Note: Clinical stage definition based on palpation, imaging.
Pathologic Stage Definition*
pNX Regional lymph nodes cannot be assessed
pN0 No regional lymph node metastasis
pN1 Metastasis in a single inguinal lymph node
pN2 Metastasis in multiple or bilateral inguinal lymph nodes
pN3 Extranodal extension of lymph node metastasis or pelvic lymph node(s) unilateral or bilateral
*Note: Pathologic stage definition based on biopsy or surgical excision
Distant Metastasis (M)
M0 No distant metastasis
M1 Distant metastasis*
*Note: Lymph node metastasis outside of the true pelvis in addition to visceral or bone sites.