Table 1: Reported cases of penile MPNST in the current literature [11-16].
Author (year) | NF1 | Age at diagnosis (years) | Size (cm) | Location | Treatment | Outcome |
Dehner (1970) | Yes | 15 | 4.0 | Prepuce, glans | Partial excision | Lost to follow-up |
Dehner (1970) | Yes | 2 | 2.5 | Dorsal shaft | Excision | Recurrence (4x) at same location in 2 years |
Aloi (1995) | No | 58 | 1 | Glans | Excision | No metastasis at 1-year follow-up |
van Eck (2006) | Not reported | 74 | Not reported | Not reported | Partial penile amputation | - Inguinal metastasis at 7 years → resection & radiation (64.8 Gy) - Gall bladder metastasis at 8 years → cholecystectomy - Multiple brain metastasis at 9 years → gamma knife surgery (2x) |
Mortell (2007) | No | 3 | 1.3 × 0.7 × 0.4 | Dorsal shaft | Excision with positive margins → re-resection at 3 months | - Local recurrence (2x) & resection (2x) at 4 and 4.5 years - No recurrence at 5.5 years |
Parekh (2013) |
No | 14 months | 5.4 × 3.7 × 3.8 | Base of penis | - Chemotherapy (2 cycles doxorubicin & ifosfamide) with 35% growth - Total penectomy (+ margins) - Radiation (5580 cGy total) | No recurrence or metastasis at 9 months |
Kaur (2015) |
No | 38 | 3.6 × 2.3 × 2.2 | Base of penis | - Resection (3 mm margin) → corpora excision - Radiation (60 Gy in 30 fractions) - Chemotherapy (6 cycles doxorubicin & ifosfamide) |
No recurrence or metastasis at 3 months |