Table 3: Up-regulated annotated genes in carbapenem resistant Pa CMC-097.
Locus_tag |
Microarray Fold Ratio |
RNA-Seq Fold Ratio |
Gene Name |
Product |
Common Pathways/Functional Classifications |
PA0513 |
4.35 |
11.77 |
nirG |
Heme d1 biosynthesis protein |
Biosynthesis of heme d1/Denitrification/Energy metabolism |
PA0517 |
8.13 |
9.63 |
nirC |
Cytochrome c55X |
Biosynthesis of heme d1/Denitrification/Energy metabolism |
PA0518 |
8.48 |
17.32 |
nirM |
Cytochrome C-551 |
Biosynthesis of heme d1 Denitrification/Energy metabolism |
PA0519 |
4.11 |
18.07 |
nirS |
Nitrite reductase |
Denitrification/Energy metabolism |
PA0567 |
5.42 |
8.16 |
yqaE |
Hypothetical protein |
Membrane proteins |
PA0887 |
5.63 |
17.12 |
acsA |
Acetyl-CoA synthetase |
Pyruvate metabolism/Central intermediary metabolism |
PA0906 |
4.1 |
1.9 |
alpR |
|
Transcriptional regulator |
PA1151 |
28.91 |
∞ |
imm2 |
Pyocin-S2 immunity protein |
Adaptation and protection |
PA1243 |
4.72 |
4155.07 |
Sensor/response regulator hybrid protein |
Two-component regulatory systems |
|
PA1705 |
4.04 |
∞ |
pcrG |
Type 3 secretion regulator |
Type 3 Secretion/Protein secretion/export apparatus |
PA1706 |
13.34 |
∞ |
pcrV |
Type 3 secretion protein |
Type 3 Secretion/Protein secretion/export apparatus |
PA1707 |
9.24 |
∞ |
pcrH |
Regulatory protein |
Type 3 Secretion/Protein secretion/export apparatus |
PA1708 |
16.04 |
∞ |
popB |
Translocator protein |
Type 3 Secretion/Protein secretion/export apparatus |
PA1710 |
17.64 |
∞ |
exsC |
Exoenzyme S synthesis protein |
Type 3 Secretion/Protein secretion/export apparatus |
PA1711 |
7.23 |
∞ |
exsE |
Hypothetical protein |
Type 3 Secretion/Protein secretion/export apparatus |
PA1718 |
86.42 |
∞ |
pscE |
Type 3 export protein |
Type 3 Secretion/Protein secretion/export apparatus |
PA1719 |
7.26 |
∞ |
pscF |
Type 3 export protein |
Type 3 Secretion/Protein secretion/export apparatus |
PA1930 |
16.66 |
2989.98 |
Chemotaxis transducer |
Chemotaxis/Adaptation and protection |
|
PA2142 |
6.04 |
5.36 |
yhxC |
Short-chain dehydrogenase |
Metabolic Enzymes |
PA2144 |
4.10 |
7.75 |
glgP |
Glycogen phosphorylase |
Metabolic Enzymes/Cell wall/LPS/capsule |
PA2146 |
7.11 |
13.39 |
yciG |
Hypothetical protein |
Metabolic Enzymes |
PA2147 |
9.02 |
22.08 |
katE |
Catalase HPII |
Metabolic Enzymes/Adaptation and protection |
PA2152 |
4.68 |
10.97 |
Trehalose synthase |
Metabolic Enzymes |
|
PA2158 |
5.54 |
9.22 |
Alcohol dehydrogenase |
Metabolic Enzymes |
|
PA2164 |
4.01 |
7.95 |
Glycosyl hydrolase |
Metabolic Enzymes/Biosynthesis of secondary metabolites |
|
PA2165 |
4.90 |
8.75 |
glgA |
Glycogen synthase |
Metabolic Enzymes/Energy metabolism |
PA2573 |
4.23 |
9.28 |
Chemotaxis transducer |
Chemotaxis/Adaptation and protection |
|
PA3038 |
4.53 |
7.11 |
opdQ |
Porin |
Transport of small molecules |
PA3187 |
6.13 |
38.98 |
gltK |
ATP-binding protein |
ABC transporters/Glucose transport |
PA3188 |
10.20 |
8.50 |
gltG |
Probable permease |
ABC transporters/Glucose transport |
PA3189 |
4.16 |
16.62 |
gltF |
Probable permease |
ABC transporters/Glucose transport |
PA3190 |
8.18 |
47.30 |
gltB |
Probable substrate-binding protein |
ABC transporters/Glucose transport |
PA3235 |
12.90 |
12.45 |
yjcH |
Hypothetical protein |
Membrane protein |
PA3719 |
9.43 |
14.64 |
armR |
MexR anti-repressor ArmR |
Antibiotic resistance and susceptibility/Beta-Lactam resistance |
PA3721 |
5.60 |
10.64 |
nalC |
Transcriptional regulator |
Antibiotic resistance and susceptibility/Beta-Lactam resistance |
PA3841 |
6.55 |
∞ |
exoS |
Exoenzyme S |
Type 3 Secretion/Secreted toxin |
PA3842 |
16.24 |
∞ |
spcS |
Chaperone |
Type 3 Secretion/Chaperone & heat shock protein |
PA4171 |
8.91 |
9.94 |
Protease |
Putative enzymes |
|
PA4218 |
4.55 |
6.43 |
Amp |
Transporter |
Antibiotic resistance and susceptibility/Membrane proteins/Transport of small molecules |
PA4220 |
7.94 |
8.21 |
fptB |
Hypothetical protein |
Hypothetical, unclassified, unknown |
PA4228 |
6.40 |
16.34 |
pchD |
2,3-dihydroxybenzoate-AMP ligase |
Pyochelin synthesis/Transport of small molecules |
PA4229 |
11.12 |
15.58 |
pchC |
Pyochelin biosynthetic protein |
Pyochelin synthesis/Transport of small molecules |
PA4230 |
4.95 |
11.12 |
pchB |
Iso-chorismate-pyruvate lyase |
Pyochelin synthesis/Transport of small molecules |
PA4231 |
4.83 |
12.66 |
pchA |
Salicylate biosynthesis iso-chorismate synthase |
Pyochelin synthesis/Transport of small molecules |
PA4276 |
4.6 |
1.8 |
SecE |
|
Preprotein translocase subunit SecE |
PA4738 |
9.22 |
6.48 |
yjbJ |
Hypothetical protein |
Metabolic pathways/Hypothetical, unclassified, unknown |
PA4773 |
4.30 |
7.42 |
speD2 |
Hypothetical protein |
Metabolic pathways/Hypothetical, unclassified, unknown |
PA4915 |
15.31 |
125.79 |
Chemotaxis transducer |
Chemotaxis/Adaptation and protection/Two-component system |
|
PA5240 |
9.0 |
1.4 |
trxA |
|
Thioredoxin |