Physicochemical properties and stability of quaternary halomethylated ammonium iodide incorporated in Precirol® nanoparticles.

Table 2: Physicochemical properties and stability of quaternary halomethylated ammonium iodide incorporated in Precirol^® nanoparticles.

Conditions		Formulations
Conditions	Parameters	Empty NPs	PC₆I
2-8 ℃^° T0	Size (nm)	112.5 ± 6.5	108.3 ± 2.2
	PI	0.2 ± 0.01	0.31 ± 0.03
	ZP mV	-25.7 ± 4.4	-16.4 ± 1.9
	%EE	NA	68.2 ± 0.03
	%DL	NA	13.7 ± 0.02
2-8 ℃^° T1	size (nm)	125.5 ± 1.5	103.1 ± 1.2
	PI	0.3 ± 0.2	0.3 ± 0.03
	ZP mV	-28.4 ± 0.5	-18.7 ± 2.8
2-8 ℃^° T2	size (nm)	133.3 ± 18.2	101.3 ± 5.1
	PI	0.3 ± 0.06	0.3 ± 0.04
	ZP mV	-18.4 ± 2.0	-8.6 ± 1.5
121℃^*	Size (nm)	94.7 ± 7.4	86.7 ± 6.1
	PI	0.3 ± 0.01	0.2 ± 0.03
	121℃*	-24.6 ± 2.9	-10.8 ± 1.4
	%EE	NA	62.8 ± 0.01
	%DL	NA	12.6 ± 0.04

Data represent mean value ± SD (n = 3). PC6I: nanoparticles of Precirol^® incorporating the quaternary halomethylated ammonium iodide C6I; PI: polydispersion index; ZP: Zeta potential; EE: Encapsulation efficiency; DL: Drug loading. 2-8 °C° T0: Fresh NPs; 2-8 °C°; T1: One month stored; 2-8 °C°; T2: Two month stored; NA: No apply. ^*during 20 min.