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Definition

Buruli ulcer case

• Lesions were clinically assessed to be consistent with Buruli ulcer lesions by experts.

• Lesions positive for M. ulcerans by PCR and positive for mycolactone detection by f-TLC from a swab or fine needle aspirates (FNA).

Surgical definitions

• Major surgery: Closure of an excised lesion using a split skin or full-thickness skin graft or vascularized tissue flap.

Long-course

Antibiotics

• Duration of antibiotics 8 weeks (56 days)

Treatment success

• Healing of the entire lesion without recurrence after the antibiotic treatment course had been completed.

Treatment outcomes

• Antibiotic treatment completed.

• Antibiotic treatment not completed.

• Healed without surgery.

• Healed with surgery.

• Healed without limitation of movement to any joint.

• Healed with limitation of movement to any joint.