Table 1: Diseases associated with both haemolysis and thrombosis.
Disease | Patients studied (n) | Thrombotic complication rate (per 100 patient years) | Venous/Arterial thrombosis |
PNH(1) | 1610 | 16%1 | Not specified |
PNH(2) | 195 | 7,37 without eculizumab vs. 1,07 with eculizumab | Without eculizumab 85/15 |
PNH (3) | 79 | 5,6 without eculizumab vs. 0,8 with eculizumab | Without eculizumab 85/15 |
PNH (4) | 301 | 18%1 | 69/31 |
AIHA (5) | 30 | 27%1 | 100/0 |
AIHA (6) | 36 | 33% without, 5% with prophylaxis2 | 75/25 |
PNH: Paroxysmal nocturnal haemolgobinuria; AIHA: Autoimmune haemolytic anaemia.
1: Cumulative incidence of thrombosis; 2: Incidence of thrombosis during haemolytic events.