Table 1: Diseases associated with both haemolysis and thrombosis.

Disease Patients studied (n) Thrombotic complication rate (per 100 patient years) Venous/Arterial thrombosis
PNH(1) 1610 16%1 Not specified
PNH(2) 195 7,37 without eculizumab vs. 1,07 with eculizumab Without eculizumab 85/15
PNH (3) 79 5,6 without eculizumab vs. 0,8 with eculizumab Without eculizumab 85/15
PNH (4) 301 18%1 69/31
AIHA (5) 30 27%1 100/0
AIHA (6) 36 33% without, 5% with prophylaxis2 75/25

PNH: Paroxysmal nocturnal haemolgobinuria; AIHA: Autoimmune haemolytic anaemia.

1: Cumulative incidence of thrombosis; 2: Incidence of thrombosis during haemolytic events.