Table 2: Warnings and Precautions Associated with VMAT2 Inhibitors [8-10].
| Warning/Precaution | Valbenazine | Tetrabenazine | Deutetrabenazine |
|---|---|---|---|
| Sedation/Somnolence | x | x | x |
| Akathisia | x | x | x |
| QTc Prolongation | x | x | x |
| Anticholinergic Effects (e.g. xerostomia, urinary retention, constipation, blurred vision) | x | ||
| Muscle Pain | x | ||
| Depression and Suicidality | x | x | |
| NMS | x | x | |
| Parkinsonism | x | x | |
| Hyperprolactinemia | x | x | |
| Binding to Melanin-Containing Tissue | x | x | |
| Dysphagia | x | ||
| Orthostatic Hypotension | x |
x: Represents the medication mentioned for that particular columnar cause the particular side effect listed for that row.