Table 2: Warnings and Precautions Associated with VMAT2 Inhibitors [8-10].
Warning/Precaution | Valbenazine | Tetrabenazine | Deutetrabenazine |
---|---|---|---|
Sedation/Somnolence | x | x | x |
Akathisia | x | x | x |
QTc Prolongation | x | x | x |
Anticholinergic Effects (e.g. xerostomia, urinary retention, constipation, blurred vision) | x | ||
Muscle Pain | x | ||
Depression and Suicidality | x | x | |
NMS | x | x | |
Parkinsonism | x | x | |
Hyperprolactinemia | x | x | |
Binding to Melanin-Containing Tissue | x | x | |
Dysphagia | x | ||
Orthostatic Hypotension | x |
x: Represents the medication mentioned for that particular columnar cause the particular side effect listed for that row.