Table 1: Dosage schedule.

Injection Date Botulinum toxin Patient III-2 Patient IV-1 Patient IV-2 Patient IV-4
1 23/11/2007 Dysport® Mentalis 15U each side (30U)
Total: 30U 		Mentalis 15U each side (30U)
Total: 30U 		Mentalis 10U each side (20U)
Total: 20U 		Mentalis 15U each side (30U)
Total: 30U
2 27/06/2008 Dysport® Mentalis 30U each side (60U)
Total: 60U 		Mentalis 30U each side (60U)
Total: 60U 		Mentalis 20U each side (40U)
Total: 40U 		Mentalis 15U each side (30U)
Total: 30U
3 16/01/2009 Dysport® Mentalis 25U each side (50U)
Total: 50U 		Mentalis 25U each side (50U)
Total: 50U 		Mentalis 15U each side (30U)
Total: 30U 		Mentalis 20U each side (40U)
Total: 40U
4 30/10/2009 Dysport® Mentalis 15U each side (30U)
Total: 30U 		Mentalis 30U each side (60U)
Total: 60U 		Mentalis 15U each side (30U)
Total: 30U 		Mentalis 20U each side (40U)
Total: 40U
5 25/06/2010 Dysport® Mentalis 15U each side (30U)
Total: 30U 		Mentalis 30U each side (60U)
Mylohyoid 20U each side
(40U)
Total: 100U 		Mentalis 15U each side
(30U)
Total: 30U 		Mentalis 20U each side
(40U)
Masseter 80U each side
(160U)
Total: 200U
6 25/02/2009 Dysport® Mentalis 20U each side (40U)
Total: 40U 		Mentalis 30U each side (60U)
Mylohyoid 25U each side
(50U)
Masseter 50U each side
(100U)
Orbicularis oris 3U each side
(6U)
Total 216U 		Mentalis 20U each side (40U)
Total: 40U 		Mentalis 20U each side (40U)
Masseter 80U each side
(160U)
Mylohyoid 20U each side
(40U)
Total: 240U
7 23/07/2011 Dysport® Mentalis 25U each side (50U)
Orbicularis oris 2U right (2U)
Total: 52U 		Mentalis 25U each side (50U)
Mylohyoid 30U each side
(60U)
Masseter 30U each side
(60U)
Orbicularis oris 5U each side
(10U)
Levator labii superioris 5U each side
(10U)
Total 190U 		Mentalis 20U each side
(40U) Total: 40U 		Mentalis 20U each side (40U)
Masseter 60U each side
(120U)
Mylohyoid 20U each side
(40U)
Total: 200U
8 27/01/2012 Dysport® Mentalis 25U each side (50U)
Orbicularis oris 4U each side (8U)
Total: 58U 		Mentalis 25U each side (50U)
Mylohyoid 30U each side
(60U)
Masseter 20U each side
(40U)
Orbicularis oris 6U each side
(12U)
Levator labii superioris 6U each side
(12U)
Total 174U 		Mentalis 20U each side (40U) Total: 40U Mentalis 20U each side (40U)
Mylohyoid 20U each side
(40U)
Orbicularis oris 6U each side
(12U)
Total: 92U
9 24/08/2012 Dysport® Mentalis 20U each side (40U)
Orbicularis oris 5U each side
(10U)
Depressor anguli oris 5U each side
(10U)
Total: 60U 		Mentalis 25U each side (50U)
Mylohyoid 30U each side
(60U)
Masseter 20U each side
(40U)
Orbicularis oris 6U each side (12U)
Total 162U 		Was not injected (pregnancy) Mentalis 20U each side (40U)
Masseter 60U each side
(120U)
Orbicularis oris 5U each side
(10U)
Total: 170U
10 14/06/2013 Botox® Mentalis 15U each side (30U)
Orbicularis oris 3U each side
(6U)
Depressor anguli oris 3U each side
(6U)
Total: 42U 		Mentalis 15U each side (30U)
Mylohyoid 15U each side
(30U)
Orbicularis oris 3U each side
(6U)
Levator labii superioris 5U
each side (10U)
Total 76U 		Mentalis 10U each side (20U)
Total: 20U
(9th injection for this patient) 		Mentalis 10U each side (20U)
Masseter 15U each side (30U)
Orbicularis oris 3U each side
(6U)
Total: 56U
11 31/01/2014 Botox® Mentalis 15U each side (30U)
Orbicularis oris 3U each side
(6U)
Depressor anguli oris 3U each side
(6U)
Total: 42U 		Mentalis 15U each side (30U)
Mylohyoid 15U each side
(30U)
Orbicularis oris 3U each side (6U)
Levator labii superioris 5U each side
(10U)
Total 76U 		Mentalis 10U each side (20U)
Total: 20U
(10th injection for this patient) 		Mentalis 10U each side (20U)
Masseter 15U each side (30U)
Orbicularis oris 3U each side
(6U)
Total: 56U
12 14/11/2014 Botox® Mentalis 15U each side (30U)
Total: 30U 		Mentalis 15U each side (30U)
Mylohyoid 15U each side
(30U)
Orbicularis oris 3U each side
(6U) Levator labii superioris 5U
each side (10U)
Total 76U 		Mentalis 15U each side (30U)
Total: 30U
(11th injection for this patient) 		Mentalis 15U each side (30U)
Orbicularis oris 3U each side
(6U)
Total: 36U
13 20/03/2015 Botox® Mentalis 20U each side (40U)
Mylohyoid 5U each side (10U)
Depressor anguli oris 3U each
side (6U)
Total: 56U 		Mentalis 20U each side (40U)
Mylohyoid 10U each side
(20U)
Orbicularis oris 4U each side
(8U)
Levator labii superioris 3U
each side (6U)
Total 74U 		Mentalis 15U each side (30U)
Total: 30U
(12th injection for this patient) 		Mentalis 15U each side (30U)
Total: 30U
14 13/11/2015 Botox® Mentalis 20U each side (40U)
Mylohyoid 5U each side (10U)
Depressor anguli oris 3U each
side (6U)
Total: 56U 		Mentalis 20U each side (40U)
Mylohyoid 10U each side
(20U)
Orbicularis oris 4U each side
(8U)
Levator labii superioris 3U
each side (6U)
Total 74U 		Mentalis 15U each side (30U)
Total: 30U
(13th injection for this patient) 		Mentalis 15U each side (30U)
Total: 30U