A Case of Acute Liver Failure Involving a Big Liver and a Small Cell
SAL Hall, T Thomas, R Pathi, KR Muller and AJ Wigg
Article Type: Case Report | First Published: March 02, 2017
Liver transplantation (LT) is an effective treatment for eligible patients with Acute Liver Failure (ALF). Prompt evaluation and decision making are required as there is often a small window of opportunity for LT before deterioration of patient health makes LT futile....
Acute Appendicitis in Pediatric Patients: An Updated Narrative Review
Abigail B Podany, Anthony Y Tsai and Peter W Dillon
Article Type: Review Article | First Published: February 21, 2017
Acute appendicitis is the most common pediatric surgical emergency worldwide. The diagnosis and management in children involves a unique set of challenges for clinicians. While the diagnosis is primarily clinical, utilization of imaging and laboratory studies can aid practitioners in making a more prompt diagnosis, preventing complications from appendiceal perforation and limiting the rate of negative appendectomies. In children special emphasis has been placed on minimizing ionizing radiation e...
Trends in Inflammatory Bowel Disease- Comparison Between the Arab and Jewish Population in Israel
Benjaminov Fabiana, Stein Assaf, Segal Ramona, Konikoff Fred M, Naftali Timna and Hermoni Doron
Article Type: Research Article | First Published: January 19, 2017
Genetic and environmental factors have a major influence on the pathophysiology of inflammatory bowel disease (IBD). Older studies reported a very low prevalence of IBD among the Arab population in Israel. Evaluate the current prevalence and disease characteristics of IBD in the Israeli-Arab population and to compare them to the Jewish population in the same area....
One Size Doesn't Fit All: IBD in Arabs and Jews in Israel, Potential Environmental and Genetic Impacts
Aaron Lerner and Torsten Matthias
Article Type: Editorial | First Published: January 07, 2017
Inflammatory bowel disease (IBD) is influenced by genetic susceptibility and surrounding environmental factors. Despite unknown etiology, the environmental factors are continuously unraveled. Studying ethnical differences in a well characterized and stable region might disclose etiologies and pathophysiological mechanism. The ethnical trends in IBD in Israel disclosed incidents, epidemiological, clinical, therapeutical and morbidity differences between the Arabs and Jews dwelling in a non-migran...
MMPs, ADAMs and Their Natural Inhibitors in Inflammatory Bowel Disease: Involvement of Oxidative Stress
Filippo Fontani, Vladana Domazetovic, Tommaso Marcucci, Maria Teresa Vincenzini and Teresa Iantomasi
Article Type: Review Article | First Published: January 05, 2017
Matrix metalloproteinases (MMPs) are enzymes involved in the degradation of extracellular matrix proteins and in several functions such as wound repair. The regulation of MMPs occurs at various levels including expression and inhibition by tissue specific inhibitors of MMPs (TIMPs). An alteration of intracellular redox state can modulate the activation and/or expression of MMPs. The increased expression and activity of MMPs are related to inflammatory state and pathogenesis of inflammatory bowel...