International Journal of

Virology and AIDSISSN: 2469-567X

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Research Article Open Access

Survival among Dually Infected HIV Patients Compared to HIV-1 Mono-Infected Patients Receiving ART in Senegal: A Twelve-Year Cohort Study

Assane Diouf, Amandine Cournil, Sabrina Eymard-Duvernay and Louise Fortes-Deguenonvo
Int J Virol AIDS Volume 3, Issue 1

Abstract: A total of 403 HIV infected patients (10 HIV-D infected and 393 HIV-1s infected) who initiated ART in Senegal between 1998 and 2002 were included in a prospective cohort and followed until June 2010. Initial ART regimens combined two nucleoside-reverse transcriptase inhibitors (NRTI) plus either one non-nucleoside-reverse transcriptase inhibitor (NNRTI) or one protease inhibitor (PI). Clinical and biological assessments were performed at ART initiation and every semester thereafter.

PDF   | Full Text  DOI: 10.23937/2469-567X/1510022

Case Report Open Access

Comprehensive Programme to Prevent Cervical Cancer - the Case of Hungary

Dobrossy L, Oroszi B, Kovacs A and Budai A
Int J Virol AIDS Volume 3, Issue 1

Abstract: The overall purpose of a comprehensive cervical cancer prevention programme is to coordinate HPV vaccination (primary prevention) and cervical screening (secondary prevention). Harmonization of the HPV vaccination and population screening is expected to reduce the burden of cervical cancer by reducing human papillomavirus (HPV) infections, and detecting cervical pre-cancer lesions and invasive cancer earlier, providing timely treatment. In 2015, 80% of 7th class schoolgirls between 12-13 years of age received HPV vaccination in Hungary. Compliance with the offered screening needs to be increased.

PDF   | Full Text  DOI: 10.23937/2469-567X/1510021

Commentary Open Access

PrEP Works, But Only When You [Have Access to] Take it: Improving PrEP Access for Young People in Chicago and Philadelphia

S Caitlin Conyngham, Cassie R Warren and Helen C Koenig
Int J Virol AIDS Volume 3, Issue 1

Abstract: The 2012 United States Food and Drug Administration approval of Tenofovir/Emtricitabine for HIV pre-exposure prophylaxis (PrEP) has added a highly effective, safe biomedical option to the HIV prevention toolbox. In the United States, young black and Latino men who have sex with men (MSM) and transgender women are disproportionately affected by HIV risk over the course of their lifetime. Nearly 1 in 10 black MSM under age 25 is infected with HIV every year, and there are more new HIV infections among young MSM of color ages 13 to 30 than in any other age or racial group.

PDF   | Full Text  DOI: 10.23937/2469-567X/1510020

Short Review Open Access

Non Alcoholic Fatty Liver Disease and Bone Fractures in Patients with HIV

Pollo-Flores P, BicudoA, Cruz-FilhoR and Soares DV
Int J Virol AIDS Volume 3, Issue 1

Abstract: Human immunodeficiency virus infection has posed a challenge for mankind and now this disease is more of a challenge for quality of life than for virus related mortality. This review aims to study two prevalent diseases that may affect this population by decreasing their quality of life. Bone fractures are much more common in the HIV-positive population and have many etiopathogenesis implicated. Non-alcoholic fatty liver disease is also common in HIV-positive patients and may even lead to cirrhosis and related complications. So it is important to search prevention and therapeutical options for these diseases and clarify the association of liver and bone as a multisystem disease and their inter-relations.

PDF   | Full Text  DOI: 10.23937/2469-567X/1510019

Short Review Open Access

Nucleoside Reverse Transcriptase Inhibitor (NRTI) Associated Macrocytosis

Wesley D. Kufel, Cory M. Hale, Eric F. Sidman, Cesar E. Orellana and Christopher D. Miller
Int J Virol AIDS Volume 3, Issue 1

Abstract: Macrocytosis has been associated with several disease states, vitamin deficiencies, and medications, with nucleoside reverse transcriptase inhibitors (NRTIs) being a less commonly identified cause. NRTIs are frequently utilized as the two-drug backbone for the treatment of Human Immunodeficiency Virus (HIV). Amongst the NRTI drug class, zidovudine (AZT) and stavudine (d4T) are the most widely reported cause of macrocytosis. Fortunately, AZT and d4T have become less commonly used therapies, as newer NRTIs with improved toxicity profiles have emerged.

PDF   | Full Text  DOI: 10.23937/2469-567X/1510018

Short Review Open Access

The AIDS Myth at 30

Erhard Geissler
Int J Virol AIDS Volume 3, Issue 1

Abstract: In 1985 the KGB and East Berlin's professor of Biology started the AIDS disinformation campaign by accusing the United States of America of having constructed and spread the AIDS agent in the course of biological weapons research. Now, 30 years later, a German authority, The Federal Commissioner for the Records of former East Germany's State Security Service, the "Stasi", is spreading disinformation regarding the alleged substantial involvement of Stasi officers in the campaign.

PDF   | Full Text  DOI: 10.23937/2469-567X/1510017

Research Article Open Access

Organotropic Kinetics in Acute Sublethal Transient Cytomegalovirus Infection in Mice

Daniel Benharroch, Ory Rouvio, Aharon Palmon and Bracha Rager
Int J Virol AIDS Volume 3, Issue 1

Abstract: Murine cytomegalovirus (MCMV) shows many similarities with the human virus (HCMV). This is a ubiquitous DNA virus from the betaherpesvirus group. A self-limiting acute phase of viral infection and a persistent latent phase normally characterize the pathogenesis of MCMV infection in the immunocompetent host. The MCMV widespread distribution occurs via the blood and its mononuclear cells. In the more common congenital viral infection, the HCMV causes birth defects, including mal-development of the central nervous system.

PDF   | Full Text  DOI: 10.23937/2469-567X/1510015

Volume 3
Issue 1