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Commentary  |   Volume 2, Issue 1

Oral Health Care to HIV-Infected Children

Gerardo Rivera Silva and Hector R Martinez Menchaca
Abstract

The prevalence of oral lesions in human immunodeficiency virus (HIV)-infected children in developed countries is equivalent to 72%, meanwhile in developing countries it equates to 60%. For this reason health professionals should identify and treat the numerous oral manifestations in HIV-infected children. There are several oral lesions that could be present in HIV-infected children.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510009

Review Article  |   Volume 2, Issue 1

Liver Fibrosis in HIV and HCV Co-Infection: Independent Mechanisms versus Collective Efforts

Jose D Debes, Paul R Bohjanen and Andre Boonstra
Abstract

Liver disease is the leading cause of death not related to AIDS in patients infected with human Immunodeficiency Virus (HIV). Patients co-infected with HIV and hepatitis C virus (HCV) experience a more rapid progression liver to fibrosis and develop hepatocellular carcinoma at a younger age than those infected with either virus alone. The mechanisms promoting this accelerated progression to fibrosis are not totally understood. Moreover, it is unclear whether both viruses exert fibrosis progression via independent paths or acting in synergy.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510008

Research Article  |   Volume 2, Issue 1

Monocyte-Derived Dendritic Cells from Feline Immunodeficiency Virus Positive Cats are Productively Infected and Maintain CD8+ T Cell Stimulatory Capacity

Hood SF, Thompson EM, Akaronu NO, Miller MM and Fogle JE
Abstract

Dendritic cells (DCs) have been utilized to enhance CD8+ T cell responses to pathogen-associated peptides for enhancement of vaccine efficacy. CD8+ T cells play a central role in the elimination of viruses during acute viral infection and control of viremia during chronic viral infection. For lentiviral infections such as HIV and FIV, dendritic cell vaccines may be useful for augmenting CD8+ T cell function.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510007

Editorial  |   Volume 2, Issue 1

International Journal of Virology and AIDS is Committed to Publishing High Quality Papers in Current Virology and AIDS Research

Christopher J. Menzie and Shu-Feng Zhou
Abstract

Understanding how viruses work and interact with the host is of the upmost importance. For example, the Ebola virus disease (formerly known as Ebola hemorrhagic fever) first appeared in 1976 in two simultaneous outbreaks, one in Nzara, Sudan, and the other in Yambuku, Democratic Republic of Congo.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510006

Research Article  |   Volume 2, Issue 1

T-reg are the Predominant CD4+ T-Cell Subset Productively Infected with HIV-1 at Sites of Dual HIV/TB Infection

Christina S Hirsch, Shigou Liu, Joy Baseke, John Lusiba Kafuluma, Mary Nserko, Harriet Mayanja-Kizza and Zahra Toossi
Abstract

Background: Regulatory T-cells (T-reg) are expanded during active tuberculosis (TB) regardless of HIV-1-infection, particularly at sites of M. tuberculosis infection. In HIV-1 disease, T-reg are targeted by HIV-1 infection. However, whether they contribute to promotion of HIV-1 infection at sites of HIV/TB is unknown. Methods: Pleural fluid mononuclear cells (PFMC) from HIV/TB patients with pleural TB were characterized by immunostaining and FACS analysis for surface markers CD4, CD127, CCR5, CXCR4 and intracellular expression of Foxp3, HIVp24, IFN-g and Bcl-2.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510005