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Case Report Open Access

Cross-Antigenicity of Paragonimus Westermani Egg Yolk Cells with Antibody against Surfactant Protein-D (SP-D) in Pulmonary Necrotizing Granuloma in a Native Japanese Woman

Yuji Ohtsuki, Shinji Fujioka, Masashi Uomoto, Yasuki Hachisuka, Masataka Korenaga, Atsushi Kurabayashi, Ichiro Murakami and Mutsuo Furihata
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: A native Japanese woman in her 60's complained of hemosputum and had an irregular nodular shadow in her chest radiograph. The nodule was surgically removed, and the histopathological findings of the pulmonary lesion showed a necrotizing granuloma with central irregular geographic necrosis associated with parasite eggs. The results of the enzyme-linked immunosorbent assay of her serum confirmed Paragonimus westermani (Pw) infection as the cause, owing to her history of ingesting uncooked wild boar meat. Interestingly, immunohistochemical results demonstrated that the Pw egg yolk cells could react with antibody against surfactant protein D (SP-D).

PDF   | Full Text   DOI: 10.23937/2378-3516/1410057

Case Report Open Access

Sarcoidosis Presenting with Severe Thrombocytopenia

Yusuf Kayar, Nuket Bayram Kayar, Nurcan Unver and Iskender Ekinci
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: Sarcoidosis is a systemic granulomatous disorder of unknown causes. Haematological manifestations in sarcoidosis are uncommon and may include haemolytic anemia, leukopenia, eosinophilia and peripheral lymphopenia, but severe thrombocytopenia is rare. Causes of thrombocytopenia in sarcoidosis were identified a few mechanisms. There are no current guidelines concerning the treatment of thrombocytopenia in sarcoidosis. However, in emergency situations with major thrombocytopenia, it seems reasonable to apply current guidelines recommended forIdiopathic Thrombocytopenic Purpura. We reported a case of sarcoidosis presenting with severe thrombocytopenia, petechial rash and gingival bleeding.

PDF   | Full Text   DOI: 10.23937/2378-3516/1410056

Original Article Open Access

Impact of Bariatric Surgery on Obstructive Sleep Apnoea in Morbidly Obese Patients; Single Centre Experience and a Literature Review

Muhammad Ali Karim, Muhammad Josheel Naveed, Amir Hussein and Abdulmajid Ali
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: Purpose: Bariatric surgery is an established treatment of morbid obesity and effectively controls symptoms of OSAHS. The aim of this study was to evaluate impact of bariatric surgery on OSAHS. Methods: Validated Epworth Sleepiness Score (ESS) and STOP-Bang questionnaires were used to assess the impact of bariatric surgery on OSAHS in morbidly obese patient's undergone bariatric surgery from May 2008 to December 2011. Change in ESS, STOP-Bang score, weight and BMI, co-morbidities and CPAP requirement were recorded. EMBASE, MEDLINE and COCHRANE database were searched for relevant literature.

PDF   | Full Text   DOI: 10.23937/2378-3516/1410055

Review Article Open Access

The Role of Histone Deacetylase Inhibitors in Myocardial Infarction

Ping Zeng and Jian Yang
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: Myocardial infarction is usually recognized as the final stage of coronary artery stenosis or occlusion in response to coronary atherosclerosis and thrombosis involving dysfunction and activation of resident vascular cells as well as the release of t-PA. As a member of family proteins for deacetylation of core histones in eukaryotic cells, Histone deacetylases are implicated in various biological processes.

PDF   | Full Text   DOI: 10.23937/2378-3516/1410054

Original Article Open Access

Role of Tissue Doppler, Strain and 3D Echocardiographic Parameters in Pulmonary Hypertension

Marta Afonso Nogueira, Luisa Moura Branco, Ana Agapito, Ana Galrinho, Alexandra Borba, Ruben Ramos, Duarte Cacela and Rui Cruz Ferreira
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: Several echocardiographic parameters study right ventricular (RV) function, which has a prognostic impact on pulmonary hypertension (PH). Our goal was to evaluate the correlation between known prognostic markers and standard, as well as advanced echocardiographic parameters, including Tissue Doppler (TDI), strain imaging and three-dimensional (3D) echocardiography.

PDF   | Full Text   DOI: 10.23937/2378-3516/1410053

Case Report Open Access

Diffuse Alveolar Hemorrhage as a Initial Manifestation of Henoch-Schonlein Purpura in Adults

Carmen Carrasco Cubero and Chamizo Carmona
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: Henoch-Schonlein purpura (HSP) is a systemic vasculitis that affects small-sized vessels, characterized by non-thrombocytopenic purpura, along with other clinical manifestations such as arthritis, abdominal pain, gastrointestinal bleeding and renal disease. Although the presence of subclinical alterations of pulmonary function has been noticed, the appearance of diffuse alveolar hemorrhage (DAH) is a rather an unusual symptom. We report a case of HSP with DAH as initial manifestation.

PDF   | Full Text   DOI: 10.23937/2378-3516/1410052

Original Article Open Access

Extubation Outcome using Cough Expiratory Flow in Surgical Patients: An Observational Study

Ming-Shian Lu, Tsung-Ming Yang, Cheng-Chih Chang, Chien-Chao Lin, Yao-Kuang Huang and Ying-Huang Tsai
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: We conducted a one-year prospective observational study of adult post-surgical patients admitted to the surgical intensive care unit and mechanically ventilated for more than 24 hours. Forced cough peak expiratory flow (FCPEF) was assessed by using a digital peak flow meter placed in-line with the endotracheal before extubation after passing previously a spontaneous breathing trial.

PDF   | Full Text   DOI: 10.23937/2378-3516/1410051

Case Report Open Access

An Unusual Case of Recurrent Post-Obstructive Pneumonia from Spontaneous Granulation Tissue Formation

Georges Al-Helou, Sripooja Satya, Brian Senisi, Robert Maximos and Jalil Ahari
Int J Respir Pulm Med Volume 3, Issue 3

Abstract: A 63-year-old man known to have human immune-deficiency viral (HIV) infection was referred for evaluation following three episodes of left upper lobe pneumonia. He was well controlled on his anti-retroviral medications. Physical exam showed left upper lobe wheezing. No evidence of obstruction could be seen on chest X-ray or computed tomography (CT). Bronchoscopy was done and showed an obstructing lesion that was biopsied then ablated. It was found to be due to a spontaneous formation of granulation tissue with no identifiable cause.

PDF   | Full Text   DOI: 10.23937/2378-3516/1410050

Volume 3
Issue 3