Hypercholesterolemic Diet: Its Effect on Colorectal Precancerous Lesions Induced by Dimethylhydrazine
Franciane da Silva Franca, Rodrigo Zeni Cora, Helena Cristina Ferreira Franz and Flavia Martinello
Article Type: Short Communication | First Published: June 30, 2016
Objective: Evaluate the effects of dietary cholesterol, without the addition of cholic acid in the initial stage of carcinogenesis and on the bifidobacteria into the colon. Methods: Rats were grouped according to their diets and dimethylhydrazine treatment (DMH): standard diet (CN); CN + cholesterol 1% (CHOL); CN + DMH (CNDMH) and CN + cholesterol 1% + DMH (CHOLDMH). After eight weeks of treatment were analyzed weight gain, faecal pH, lipid profile, hepatic and faecal cholesterol, faecal bifidob...
Japanese Crisis of HPV Vaccination
Masayuki Sekine, Risa Kudo, Sosuke Adachi, Manako Yamaguchi, Yutaka Ueda, Tomomi Takata, Akiko Morimoto, Yusuke Tanaka, Asami Yagi, Etsuko Miyagi and Takayuki Enomoto
Article Type: Review Article | First Published: May 30, 2016
Cervical cancer has been increasing in younger generation, especially in 20's and 30's, so it has been a serious problem that the disease leads to loss of fertility as an urgent issue in Japan. HPV vaccine was added to the national list of routine vaccinations for Japanese girls aged 12 to 16 years by law since April, 2013. Three months later, however, the Japanese Ministry of Health, Labour, and Welfare suspended recommendations for HPV vaccination after several reports of possible adverse even...
Myofibroblasts Role in Wound Healing of Εyelid Lesions
Trisevgeni Ntinioti, Georgia-Heleni Thomopoulou, Eugene Danas, Nikolaos G Kavantzas, Emmanuel Agapitos and Andreas C Lazaris
Article Type: Letter to the Editor | First Published: May 25, 2016
In injured tissues, the repair of the extracellular matrix is organized by activated myofibroblasts. The latter cells support harmonious mechanical tissue organization. At the end of the normal repair process, myofibroblasts disappear by apoptosis but in pathological situations, myofibroblasts likely remain leading to excessive scarring. The eyelids are movable folds of tissue the core of which is represented by a tarsal plate, composed of dense connective tissue, embedded in loose connective ti...
Atypical Retinal Arterial Macroaneurysm
Hans Hoerauf, Philipp Steven and Nicolas Feltgen
Article Type: Case Report | First Published: May 25, 2016
A patient with an atypical retinal arterial macroaneurysm masked by a persistent vitreous haemorrhage mimicking a neoplasm is presented. During vitrectomy a pigmented peripapillary tumour located at large vessels with circinate lipid exsudates was detected. Examination of removed tissue revealed haemosiderin-loaded macrophages resulting in pigmentation. The histologic finding of phagocytosis of intraretinal blood remnants allowed to diagnose an atypical retinal arterial macroaneurysm....
BRAF V600E Immunohistochemistry in Cutaneous Langerhans Cell Histiocytosis: An Analysis of 20 Cases
Ryan C Romano, Wonwoo Shon, Sarah M Jenkins and Karen J Fritchie
Article Type: Review Article | First Published: May 25, 2016
Twenty dermatologic biopsy specimens from 14 patients (9 adults and 5 children) were retrieved. All cases were immunostained with BRAF mutation-specific antibody. Selected BRAF V600E IHC-positive cases were analyzed for BRAF V600E mutation by pyrosequencing. Clinical parameters were correlated with IHC status. BRAF V600E protein overexpression was identified in 15 of 20 (75%) cases (9/14 patients; 5 adults and 4 children). All pediatric patients with bone involvement were BRAF V600E IHC positive...
Severe Complication of POPS: Mesh Malposition in the Bladder
Sabine Kersting, Dirk Kusche, Klaus-PeterJung and Eugen Berg
Article Type: Case Report | First Published: April 30, 2016
The authors present a case of a 68-years-old woman suffering of persistent urinary tract infections accompanied by intermittent fever. She had a history of pelvic organ prolapse suspension (POPS) for descending perineal syndrome with rectal prolapse, carried out elsewhere 15 months ago. Cystoscopy revealed a part of the prolene mesh that was incrusted along the fundus of the bladder to be the source of symptoms. This is probably the first case that reports a complication of POPS, which is a rela...
Opana-Induced Renal and Hepatic Injury: A Case Report and Review
Yahya M Kurdi, Sergey Brodsky and Martha Yearsley
Article Type: Case Report and Literature Review | First Published: April 30, 2016
A 34-year-old Caucasian female presented with headache, fatigue, mild abdominal pain, and dehydration. She admitted to intravenous abuse of "melted" Opana ER tablets (extended-release oral formulation of oxymorphone hydrochloride). Noted clinical signs included tachycardia, tachypnea, and trace peripheral edema. Abnormal laboratory tests included low creatinine clearance, hemoglobin, hematocrit, and platelet. Histological studies of hepatorenal biopsies showed evidence of severe active thromboti...
Anaplastic Large Cell Lymphoma as a Potential Diagnostic Challenge and Pitfall in Aspiration Biopsies of Thoracic Tumours
Justin Bateman, Celeste Morley, Bruce F. Burns and Shahid Islam
Article Type: Case Report and Literature Review | First Published: April 01, 2016
The patient is a 54 year-old male who presented in January 2015 with increasing dyspnea and weight loss over several months, eventually requiring intubation and admission to ICU for respiratory failure. He had a remote history of testicular seminoma and 'melanoma'. A trans-bronchial Wang needle aspirate biopsy of the right sub-carinal lymph node was preformed and showed sheets of large malignant cells with pleomorphic nuclei, multiple prominent nucleoli, and abundant cytoplasm. The tumour cells ...
Epigenomic Explanations for the Uncertainty of Cancer Biomarkers
Shou-Tung Chen, Chia-Chen Hsu, Yu-Wei Leu and Shu-Huei Hsiao
Article Type: Review Article | First Published: April 01, 2016
Inheritable epigenetic modifications, like histone modifications and DNA methylation, were once considered somatically stable and tissue-specific, yet accumulating evidence suggests the contrary. Environmental encounters are transduced into the cell through signaling pathways and these signals are relayed to the nucleus and memorized as epigenetic marks on target genes. Signaling-specific epigenomic changes provide selectable outlines for further lineage determination during differentiation and ...
BerEP4 and AE1/3 are Reliable Markers of Epithelial Content for Biomarker Discovery Using Reverse Phase Protein Arrays (RPPA)
Ola H Negm, James C Hassall, Wakkas Fadhil, Alain Pitiot, Patrick J Tighe, Cedric Marchessoux and Mohammad Ilyas
Article Type: Mini Review | First Published: April 01, 2016
Biomarker studies are notorious for their high failure rate. Despite huge investment by both academia and industry, very few biomarkers make the transition from interesting laboratory data to tests with clinical utility. The reasons for this are manifold. Some biomarkers are "true" biomarkers inasmuch as they are robust and reproducible but the information they provide does not help to improve patient management beyond that informed by traditional clinical parameters....