Open Access DOI:10.23937/2469-5807/1510030
Reduced and Thinned Elastic Fibers in Skin Tag
Ahmed Abdullah Alhumidi
Article Type: Mini Review | First Published: March 29, 2016
This is a retrospective study in which thirty histopathological specimens of fibroepithelial polyp (skin tag) were examined. Their paraffin blocks were collected from the archives of the Pathology Department, king khalid University hospital, Riyadh, Saudi Arabia, during the period from 2010 to 2012. Age of the patient, sex, and site, of the lesions as well as type of skin tag were recorded. Sections from each paraffin block were cut by a microtome at 5-micron thickness, stained with hematoxylin ...
Open Access DOI:10.23937/2469-5807/1510029
Micronutrients Deficiencies in Rheumatoid Arthritis Patients
Graziela Biude Silva, Bruna Zavarize Reis and Silvia Maria Franciscato Cozzolino
Article Type: Mini Review | First Published: February 29, 2016
Rheumatoid arthritis (RA) is a chronic inflammatory disease that predominantly involves synovial joints and affects up to 2% of adults worldwide. Poor nutrient status in RA patients has been reported and some drug therapies, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prescribed to alleviate RA symptoms, may increase the requirement for some nutrients and reduce their absorption. The importance of micronutrients in this disease is related to their cofactor role in immune system functi...
Open Access DOI:10.23937/2469-5807/1510028
Research Progress of STK33 in Cancer Biology
Chen Chen and Jianfeng Li
Article Type: Mini Review | First Published: February 29, 2016
In recent years, serine/threonine kinase 33 (STK33) has attracted considerable attention in tumor biology. STK33 displays a heterogenous expression pattern, and in most tissues, expression level is low. It belongs to the CAMK family, and differentiates itself from other members of the CAMK family due to its expression pattern. STK33 is likely to participate in the dynamic changes of intermediate filament cytoskeleton depolymerization by phosphorylating vimentin, and thereby influencing the cell ...
Open Access DOI:10.23937/2469-5807/1510027
JAK2V617F Mutation Affects Downstream LIN28A and HMGA2 Methylation in Myeloproliferative Neoplasms
Chih-Cheng Chen, Chia-Chen Hsu, Kuan-Der Lee, Chia-Chen Chiu, Hong-Chi Chen, Tim H.-M. Huang, Yu-Wei Leu and Shu-Huei Hsiao
Article Type: Mini Review | First Published: February 29, 2016
The lineage/clonal selection theory for cellular transformation may help identify the effector genes whose functions are crucial for MPN tumorigenesis. MPNs originate from hematopoietic stem cells carrying compartmental mutations such as JAK2V617F. JAK2 signaling regulates target gene expression by altering the phosphorylation and nuclear localization of STATs. To provide selectable gene expression that promotes transformation of certain cellular lineages, specific signals relayed to the cell nu...
Open Access DOI:10.23937/2469-5807/1510026
The Cardiovascular Risk Prognostication in Diabetes Mellitus: The Role of Myeloid-related Protein Complex Calprotectin
Alexander E. Berezin
Article Type: Mini Review | First Published: February 26, 2016
The low-intense inflammation is discussed as a one of the clue of various faces of pathogenesis of diabetes mellitus (DM) including insulin resistance, mitochondrial dysfunction, lipotoxity, oxidation injury that contributed in cardiovascular (CV) disease and clinical outcomes. However, there are a lot of candidates for on early biological marker that could stratify DM patients at CV risk. The myeloid-related protein 8/14 known as calprotectin is a heterodimeric complex of calcium-binding protei...
Open Access DOI:10.23937/2469-5807/1510025
Integration to Advance Translation
Estela S. Estape
Article Type: Commentary | First Published: February 26, 2016
The science of translation has been taken over very fast by health stakeholders such as: investors, shareholders, sponsors, practitioners or any interested party in healthcare. The main reason is the demand to transfer discoveries faster to the ones who are in most need: the participants or patients. Translation can be seen as the art of transferring scientific knowledge into evidenced based everyday practice; paving the way to increased effectiveness and efficiency in health care. The concept o...
Open Access DOI:10.23937/2469-5807/1510023
Glutamate Concentrations in Plasma and CSF in Patients with Glioma and Meningioma
George Dimogerontas, Alexia Polissidis, Petros Karkalousos, Epameinondas Konstantinidis, Zeta Papadopoulou-Daifoti and Charis Liapi
Article Type: Review Article | First Published: February 07, 2016
Glioma, a malignant intra-axial brain tumor, can release glutamate that facilitates tumor expansion, stimulates tumor-cell proliferation and motility and promotes epileptic activity. Glutamate acid is the major excitatory neurotransmitter in the mammalian Central Nervous System. We explore correlations of glutamate concentrations in blood and cerebrospinal fluid in patients with glioma in comparison to patients with meningioma which is the most common benign cerebral tumor....
Open Access DOI:10.23937/2469-5807/1510020
A De Novo Malignant Mixed Tumor (Carcinosarcoma) of the Parotid Gland: Case Report
Hussam F Tallab, David E Ricklan and Peter J Catalano
Article Type: Case Report | First Published: January 29, 2016
True malignant mixed tumors (carcinosarcomas) of salivary gland origin are exceedingly rare and demonstrate malignant epithelial and stromal components. The subject of this case study is a 61 year-old male who presented with mild left facial swelling with minimal discomfort and without a mass of the parotid gland. He underwent CT imaging which demonstrated a cystic lesion of the parapharyngeal space. CT guided fine needle aspiration of the lesion failed to demonstrate malignancy. The patient ult...
Open Access DOI:10.23937/2469-5807/1510019
Anemia Investigation Reveals a Primary Sea-Blue Histiocyte Syndrome
Antonio Proenca Caetano, Ines de Figueiredo, Francisco Tortosa, Anabela Ferrao and Cristina Ferreira
Article Type: Case Report and Review of Literature | First Published: January 08, 2016
Sea-blue Histiocyte Syndrome (SBHS) is a rare and poorly understood systemic histiocytosis that is sometimes associated with haematological and lipid storage diseases as well as other miscellaneous conditions, but in most cases its cause is unknown. Patients often have very disparate clinical features but share the same histological findings of sea-blue histiocytosis in the bone marrow, i.e. characteristic lipid-laden macrophages with deep-blue or blue-green granules when stained with Romanovsky...